The compressional behavior of strontianite SrCO₃ was investigated at ambient temperature and high pressure, using a diamond anvil cell (DAC) with Ne as a pressure transmitting medium. X-ray diffraction patterns were collected to ~52 GPa using in situ angle-dispersive synchrotron-based powder X-ray diffraction (XRD). A phase transition was observed at ~20 GPa, and no indications of further transitions were detected up to ~52 GPa. The pressure-volume (P-V) data within 0.27-17.35 GPa were fitted to a third-order Birch-Murnaghan equation of state (BM3 EoS) to obtain the elastic coefficients including zero-pressure unit-cell volume, isothermal bulk modulus and its pressure derivative: V₀ = 258.4(3) ų, K_T0 = 55(2) GPa, and K′_T0 = 4.3(3). The V₀ and K_T0 were obtained as 258.1(2) ų and 57.1(6) GPa, when fixed K′_T0 = 4. The axial compressional behavior of strontianite was also investigated by fitting the pressure-lattice parameter data to a parameterized form of the BM3 EoS, and the compression of the a-, b-, and c-axis was strongly anisotropic, with K_a0 = 104(6), K_b0 = 52(12), and K_c0 = 31.6(5) GPa. Based on this and previous studies using different pressure transmitting media (PTM), the effects PTM on the compressional behavior of strontianite were discussed.