Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release | |
Shi, B; Ren, N; Gu, LY; Xu, G; Wang, RC; Zhu, TL; Zhu, Y; Fan, CH; Zhao, CC; Tian, H | |
刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION |
2019 | |
卷号 | 58期号:47页码:16826-16830 |
关键词 | PHOTODYNAMIC THERAPY CANCER H2S NANOPARTICLES |
ISSN号 | 1433-7851 |
DOI | 10.1002/anie.201909883 |
文献子类 | 期刊论文 |
英文摘要 | NIR light responsive nanoplatforms hold great promise for on-demand drug release in precision cancer medicine. However, currently available systems utilize "always-on" photothermal transducers that lack target specificity, and thus inaccurately differentiate tumors from normal tissues. Developed here is a theranostic nanoplatform featuring H2S-mediated in situ production of NIR photothermal agents for imaging-guided and photocontrolled drug release. The system targets H2S-rich cancers. This nanoplatform shows H2S-activatable NIR-II emission and NIR light controllable release of the drug Camptothecin-11. Upon administering the system to HCT116 tumor-bearing mice, the tumor is greatly suppressed with minimal side effects, arising from the synergy of the cancer-specific and NIR light activated therapy. This theranostic nanoplatform thus sheds light on precision medicine with guidance through NIR-II imaging. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.sinap.ac.cn/handle/331007/32251] |
专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
作者单位 | 1.East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China; 2.East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China; 3.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys,Shanghai Synchrotron Radi, Shanghai Adv Res Inst,Div Phys Biol,Zhangjiang La, Shanghai 201800, Peoples R China; 4.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys,Bioimaging Ctr, Shanghai Adv Res Inst,Zhangjiang Lab,Shanghai Syn, Shanghai 201800, Peoples R China; 5.Shanghai Jiao Tong Univ, Renji Hosp, Sch Chem & Chem Engn, Sch Med, Shanghai 200240, Peoples R China; 6.Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med, Sch Med, Shanghai 200240, Peoples R China |
推荐引用方式 GB/T 7714 | Shi, B,Ren, N,Gu, LY,et al. Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(47):16826-16830. |
APA | Shi, B.,Ren, N.,Gu, LY.,Xu, G.,Wang, RC.,...&Tian, H.(2019).Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(47),16826-16830. |
MLA | Shi, B,et al."Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.47(2019):16826-16830. |
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