Gold nanoflower-based surface-enhanced Raman probes for pH mapping of tumor cell microenviroment

doi:10.1111/cpr.12618

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Gold nanoflower-based surface-enhanced Raman probes for pH mapping of tumor cell microenviroment
	Xie, M ; Li, F ; Gu, PL ; Wang, F ; Qu, ZB ; Li, J ; Wang, LH ; Zuo, XL ; Zhang, XL ; Shen, JL
刊名	CELL PROLIFERATION
	2019
卷号	52 期号:4 页码:-
关键词	CANCER STATISTICS SCATTERING SERS NANOPARTICLES SIZE NANOSTRUCTURES SILVER TAGS
ISSN号	0960-7722
DOI	10.1111/cpr.12618
文献子类	期刊论文
英文摘要	Objectives Early diagnosis of tumour cells is critically important for cancer treatment. Given that the tumour environment is slightly acidic, the pH value of the cell environment can be used as a criterion for tumour diagnosis. However, mapping pH in the cell environment with high resolution, high sensitivity and accuracy remains challenging. Materials and Methods Based on gold nanoflower as surface-enhanced Raman scattering (SERS) substrate loading with p-mercaptobenzoic acid (MPA) as pH-responsive Raman reporter, a new SERS nanoprobe for pH mapping was developed. Results This probe showed a characteristic Raman spectrum signal in response to the different pH in solutions or cells. The signal intensity is positively correlated to the pH value. Moreover, this probe is self-correctable, which can help eliminate the influence of probe concentration on the accuracy of pH measuring. Conclusions We demonstrate the pH mapping of cell environment using the probe, which can be used to distinguish normal cells and tumour cells. This method may provide a new imaging tool for early diagnosis of cancer.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/32072]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Univ Chinese Acad Sci, Beijing, Peoples R China; 2.Southern Med Univ, Affiliated Fengxian Hosp, Affiliated Peoples Hosp 6, South Campus, Shanghai 201499, Peoples R China 3.Shanghai Jiao Tong Univ, Joint Res Ctr Precis Med, Shanghai, Peoples R China; 4.Shanghai Jiao Tong Univ, Inst Mol Med, Sch Med, Renji Hosp, Shanghai, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China;
推荐引用方式 GB/T 7714	Xie, M,Li, F,Gu, PL,et al. Gold nanoflower-based surface-enhanced Raman probes for pH mapping of tumor cell microenviroment[J]. CELL PROLIFERATION,2019,52(4):-.
APA	Xie, M.,Li, F.,Gu, PL.,Wang, F.,Qu, ZB.,...&Shen, JL.(2019).Gold nanoflower-based surface-enhanced Raman probes for pH mapping of tumor cell microenviroment.CELL PROLIFERATION,52(4),-.
MLA	Xie, M,et al."Gold nanoflower-based surface-enhanced Raman probes for pH mapping of tumor cell microenviroment".CELL PROLIFERATION 52.4(2019):-.