DNA-Based Hybrid Hydrogels Sustain Water-Insoluble Ophthalmic Therapeutic Delivery against Allergic Conjunctivitis

doi:10.1021/acsami.9b08652

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	DNA-Based Hybrid Hydrogels Sustain Water-Insoluble Ophthalmic Therapeutic Delivery against Allergic Conjunctivitis
	Ren, N ; Sun, R ; Xia, K ; Zhang, Q ; Li, W ; Wang, F ; Zhang, XL ; Ge, ZL ; Wang, LH ; Fan, CH
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019
卷号	11 期号:30 页码:26704-26710
关键词	CELLS NANOPARTICLES RELEASE
ISSN号	1944-8244
DOI	10.1021/acsami.9b08652
文献子类	期刊论文
英文摘要	Clinical need for treating allergic conjunctivitis (AC) is rapidly increasing. However, AC-relevant anti-inflammatory compounds are generally difficult to solubilize in water, thus limiting their therapeutic potential. Solubility-improved eye drop formulations of these compounds have poor bioavailability and a short retention time in ophthalmic tissues. Herein, we report a DNA/poly(lactic-co-glycolicacid) (PLGA) hybrid hydrogel (HDNA) for water-insoluble ophthalmic therapeutic delivery. PLGA pre-encapsulation enables loading of water-insoluble therapeutics. HDNA's porous structure is capable of sustained delivery of therapeutics. Dexamethasone (DEX), with demonstrated activities in attenuating inflammatory symptom in AC, was used as a model system. The designed HDNA hybrid hydrogels significantly improved the DEX accumulation and mediated the gradual DEX release in ophthalmic cells and tissues. Using the HDNA DEX complexes, potent efficacy in two animal models of AC was acquired. Given this performance, demonstrable biocompatibility, and biodegradability of DNA hydrogel, the HDNA-based ophthalmic therapeutic delivery system enables novel treatment paradigms, which will have widespread applications in the treatment of various eye diseases.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/32028]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Southern Med Univ, Affiliated Peoples Hosp 6, Affiliated Fengxian Hosp, South Campus, Shanghai 201499, Peoples R China; 2.Univ Chinese Acad Sci, Div Phys Biol, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys,Chinese Acad Sci, Shanghai 201800, Peoples R China; 3.Univ Chinese Acad Sci, Bioimaging Ctr, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys,Chinese Acad Sci, Shanghai 201800, Peoples R China; 4.Shanghai Jiao Tong Univ, Joint Res Ctr Precis Med, Shanghai 201499, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Ren, N,Sun, R,Xia, K,et al. DNA-Based Hybrid Hydrogels Sustain Water-Insoluble Ophthalmic Therapeutic Delivery against Allergic Conjunctivitis[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(30):26704-26710.
APA	Ren, N.,Sun, R.,Xia, K.,Zhang, Q.,Li, W.,...&Zhu, Y.(2019).DNA-Based Hybrid Hydrogels Sustain Water-Insoluble Ophthalmic Therapeutic Delivery against Allergic Conjunctivitis.ACS APPLIED MATERIALS & INTERFACES,11(30),26704-26710.
MLA	Ren, N,et al."DNA-Based Hybrid Hydrogels Sustain Water-Insoluble Ophthalmic Therapeutic Delivery against Allergic Conjunctivitis".ACS APPLIED MATERIALS & INTERFACES 11.30(2019):26704-26710.