C-28 steroids from the fruiting bodies of Ganoderma resinaceum with potential anti-inflammatory activity

doi:10.1016/j.phytochem.2019.112109

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	C-28 steroids from the fruiting bodies of Ganoderma resinaceum with potential anti-inflammatory activity
	Shi, Qiangqiang 1,2,3; Huang, Yanjie 1,2,3; Su, Haiguo 1,2,3; Gao, Ya 1,2,3; Peng, Xingrong 1,3; Zhou, Lin 1,3; Li, Xiaonian 1,3; Qiu, Minghua 1,2,3
刊名	PHYTOCHEMISTRY
	2019-12-01
卷号	168 页码:8
关键词	Ganoderma resinaceum boud Ganodermataceae Ergostane-type Steroids Anti-inflammatory activity
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2019.112109
通讯作者	Qiu, Minghua(mhchiu@mail.kib.ac.cn)
英文摘要	Eight undescribed ergostane-type steroids, (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha-diol- 6,5-olide, (22E,24R)-er-gosta-7,9(11),22-trien-3 beta,5 beta,6 beta-triol, (22E,24R)-6 beta-methoxy ergosta-7,9(11),22-trien-3 beta,5 alpha,14 beta-triol, (22E,24R)-9 alpha,15 alpha-dihydroxyergosta-4,6,8 (14),22-tetraen-3-one, (22E,24R)-ergosta-5,8,22-trien-3 beta,11 alpha-dihydroxyl-7-one, (22E,24R)-ergosta-4,7,22-trien-3 beta,9 alpha,14 beta-trihydroxy1-6-one, (22E,24R)-ergosta-7,22- dien-3 beta,9 alpha,14 beta-trihydroxy1-6-one, and (22E,24R)-6 beta-methoxyergosta-7,22-dien-3 beta, 5 alpha,9 alpha,14 beta-tetraol, and twentyone known analogues were isolated from the fruiting bodies of Ganoderma resinaceum Boud. Their chemical structures were determined on the basis of comprehensive spectroscopic analysis and X-ray crystal diffraction, as well as empirical pyridine-induced deshielding effects. Furthermore, selected compounds were evaluated for their inhibitory effects on macrophage activation using an inhibition of nitric oxide production assay. Finally, (22E,24R)-ergosta-5,8,22- trien-3/3,11 alpha-dihydroxy1-7-one, (22E,24R)-ergosta-4,7,22-trien-3 beta,9 alpha,14 beta-tri hydroxyl-6-one, (22E,24R)-6 beta-methoxyergosta-7,22-dien-3 beta,5 alpha,9 alpha,14 beta-tetrao1, (22E,24R)-ergosta-6,9,22-trien-3 beta,5 alpha,8 alpha-triol,ergost-6,22-dien-3 beta,5 alpha,8 alpha-triol, 5 alpha,6 alpha-epoxy-(22E,24R)-ergosta-8,22-diene-3 beta,7 alpha-diol, 5 alpha,6 alpha-epoxy-(22E,24R)- ergosta-8(14),22-diene-3 beta,7 alpha-diol, 5 alpha,6 alpha-epoxy-(22E,24R)-ergosta-8(14),22-diene-3 beta, 7 beta-diol, and 22E-7 alpha-methoxy-5 alpha,6 alpha-epoxyergosta-8(14),22-dien-3 beta-ol showed inhibitory effects on NO production with IC50 values ranging from 3.24 +/- 0.02 to 35.19 0.41 mu M compared with L-NMMA (IC50 49.86 +/- 2.13 mu M), indicating that they have potential anti-inflammatory activity.
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
WOS记录号	WOS:000496894000005
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/70920]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Qiu, Minghua
作者单位	1.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Shi, Qiangqiang,Huang, Yanjie,Su, Haiguo,et al. C-28 steroids from the fruiting bodies of Ganoderma resinaceum with potential anti-inflammatory activity[J]. PHYTOCHEMISTRY,2019,168:8.
APA	Shi, Qiangqiang.,Huang, Yanjie.,Su, Haiguo.,Gao, Ya.,Peng, Xingrong.,...&Qiu, Minghua.(2019).C-28 steroids from the fruiting bodies of Ganoderma resinaceum with potential anti-inflammatory activity.PHYTOCHEMISTRY,168,8.
MLA	Shi, Qiangqiang,et al."C-28 steroids from the fruiting bodies of Ganoderma resinaceum with potential anti-inflammatory activity".PHYTOCHEMISTRY 168(2019):8.