Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum

doi:10.1007/s00044-020-02506-7

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum
	Dong, Jinrun 2; Yue, Grace Gar-Lee 1,3; Lee, Julia Kin-Ming 1,3; Lau, Clara Bik-San 1,3; Qiu, Minghua 2
刊名	MEDICINAL CHEMISTRY RESEARCH
	2020-01-17
页码	7
关键词	Cynanchum otophyllum Neurotrophic activity Cytotoxicity Colon cancer cells
ISSN号	1054-2523
DOI	10.1007/s00044-020-02506-7
通讯作者	Lau, Clara Bik-San(claralau@cuhk.edu.hk) ; Qiu, Minghua(mhchiu@mail.kib.ac.cn)
英文摘要	Cynanchum otophyllum was traditionally used for treating muscle and skeletal pain, epilepsy, abdominal pain, and tightness. Four known C21 steroidal glycosides, namely caudatin 3-O-beta-cymaropyranoside (1), caudatin 3-O-beta-D-cymaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (2), otophylloside B (3), and otophylloside A (4) were isolated from the roots of this plant and their neurotrophic activities were examined in rat neuronal PC12 cell model, while their cytotoxicities were evaluated in human cancer cells and normal fibroblasts. Differential promoting effects on neurite-bearing cells were found among testing compounds, with 2 the most potent. On the other hand, selective cytotoxicity against human colon cancer cells HCT-116 of 2 was firstly demonstrated here. Besides, 2 induced inhibitory activities on cancer cell proliferation, sphere formation and interfered the cell cycle. The new potential pharmacological activities of 2 on colon cancer cells were revealed in the present study.
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000507790700001
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/70628]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Lau, Clara Bik-San; Qiu, Minghua
作者单位	1.Chinese Univ Hong Kong, State Key Lab Res Bioact & Clin Applicat Med Plan, Shatin, Hong Kong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China 3.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Dong, Jinrun,Yue, Grace Gar-Lee,Lee, Julia Kin-Ming,et al. Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum[J]. MEDICINAL CHEMISTRY RESEARCH,2020:7.
APA	Dong, Jinrun,Yue, Grace Gar-Lee,Lee, Julia Kin-Ming,Lau, Clara Bik-San,&Qiu, Minghua.(2020).Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum.MEDICINAL CHEMISTRY RESEARCH,7.
MLA	Dong, Jinrun,et al."Potential neurotrophic activity and cytotoxicity of selected C21 steroidal glycosides from Cynanchum otophyllum".MEDICINAL CHEMISTRY RESEARCH (2020):7.