Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces
	Wang Lei 2,3,4; Wang Li 3,4,5; Zhou Zhi 1,3,4,5; Wang Yong-Jiang 3,4,5; Huang Jian-Ping 3,4; Ma Ya-Tuan 2; Liu Yang 1; Huang Sheng-Xiong 3,4
刊名	CHINESE JOURNAL OF NATURAL MEDICINES
	2019-12-01
卷号	17 期号:12 页码:982-987
关键词	Streptomyces Angucyclinones Benz[a]anthracenes Natural products Immunosuppressive activity
ISSN号	2095-6975
通讯作者	Huang Sheng-Xiong(sxhuang@mail.kib.ac.cn)
英文摘要	Cangumycins A-F (1-6), six new angucyclinone analogues, together with two known ones (7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E (5) and F (6) share a C-ring cleaved backbone, and cangumycins B (2) and E (5) exhibit potent immunosuppressive activity (IC50 8.1 and 2.7 mu mol.L-1, respectively) against human T cell proliferation at a non-cytotoxic concentration.
WOS研究方向	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000504330400016
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/70556]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Huang Sheng-Xiong
作者单位	1.Chengdu Med Coll, Res Ctr, Chengdu 610500, Sichuan, Peoples R China 2.Northwest Agr & Forestry Univ, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang Lei,Wang Li,Zhou Zhi,et al. Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(12):982-987.
APA	Wang Lei.,Wang Li.,Zhou Zhi.,Wang Yong-Jiang.,Huang Jian-Ping.,...&Huang Sheng-Xiong.(2019).Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces.CHINESE JOURNAL OF NATURAL MEDICINES,17(12),982-987.
MLA	Wang Lei,et al."Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces".CHINESE JOURNAL OF NATURAL MEDICINES 17.12(2019):982-987.