Disrupted pathways from limbic areas to thalamus in schizophrenia highlighted by whole-brain resting-state effective connectivity analysis | |
Hua, Minghui1,8; Peng, Yanmin1,8; Zhou, Yuan5,6,7; Qin, Wen3,4; Yu, Chunshui1,2,3,4,8; Liang, Meng1,8 | |
刊名 | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY |
2020-04-20 | |
卷号 | 99页码:10 |
关键词 | Functional MRI Functional connectivity Multivariate pattern analysis Granger causality Pattern classification |
ISSN号 | 0278-5846 |
DOI | 10.1016/j.pnpbp.2019.109837 |
英文摘要 | Background: Numerous neuroimaging studies have revealed that schizophrenia was characterized by widespread dysconnection among brain regions during rest measured by functional connectivity (FC). In contrast with FC, effective connectivity (EC) provides information about directionality of brain connections and is thus valuable in mechanistic investigation of schizophrenic brain. However, a systematic characterization of whole-brain resting-state EC (rsEC) and how it captures different information compared with resting-state FC (rsFC) in schizophrenia are still lacking. Aims: To systematically characterize the abnormalities of rsEC, compared with rsFC, in schizophrenia, and to test its discriminative power as a neuroimaging marker for schizophrenia diagnosis. Method: Whole-brain rsEC and rsFC networks were constructed using resting-state fMRI data and compared between 103 patients with schizophrenia and 110 healthy participants. Pattern classifications between patients and controls based on whole-brain rsEC and rsFC were further performed using multivariate pattern analysis. Results: We identified 17 rsEC significantly disrupted (mostly decreased) in patients, among which all were associated with the thalamus and 15 were from limbic areas (including hippocampus, parahippocampus and cingulate cortex) to the thalamus. In contrast, abnormal rsFC were widely distributed in the whole brain. The classification accuracies for distinguishing patients and controls using whole-brain rsEC and rsFC patterns were 78.6% and 82.7%, respectively, and was further improved to 84.5% when combining rsEC and rsFC. Conclusions: Schizophrenia is featured by disrupted 'limbic areas-to-thalamus' rsEC, in contrast with diffusively altered rsFC. Moreover, both rsEC and rsFC contain valuable and complementary information which may be used as diagnostic markers for schizophrenia. |
资助项目 | National Key R&D Program of China[2017YFC0909201] ; National Key R&D Program of China[2018YFC1314300] ; National Natural Science Foundation of China[81571659] ; National Natural Science Foundation of China[81971694] ; National Natural Science Foundation of China[81971599] ; National Natural Science Foundation of China[81771818] ; Tianjin Key Technology RD Program[17ZXMFSY00090] ; Natural Science Foundation of Tianjin[19JCYBJC25100] |
WOS关键词 | FUNCTIONAL CONNECTIVITY ; GRANGER CAUSALITY ; DEFAULT MODE ; CLASSIFICATION ; ABNORMALITIES ; NETWORK ; MATTER ; MEMORY ; RISK |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000518756400012 |
资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Tianjin Key Technology RD Program ; Natural Science Foundation of Tianjin |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/31376] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Liang, Meng |
作者单位 | 1.Tianjin Med Univ, Sch Med Imaging, 1 Guangdong Rd, Tianjin 300203, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China 3.Tianjin Med Univ Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China 4.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China 7.Chinese Acad Sci, CAS Key Lab Behav Sci, Inst Psychol, Beijing, Peoples R China 8.Tianjin Med Univ, Tianjin Key Lab Funct Imaging, Tianjin, Peoples R China |
推荐引用方式 GB/T 7714 | Hua, Minghui,Peng, Yanmin,Zhou, Yuan,et al. Disrupted pathways from limbic areas to thalamus in schizophrenia highlighted by whole-brain resting-state effective connectivity analysis[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2020,99:10. |
APA | Hua, Minghui,Peng, Yanmin,Zhou, Yuan,Qin, Wen,Yu, Chunshui,&Liang, Meng.(2020).Disrupted pathways from limbic areas to thalamus in schizophrenia highlighted by whole-brain resting-state effective connectivity analysis.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,99,10. |
MLA | Hua, Minghui,et al."Disrupted pathways from limbic areas to thalamus in schizophrenia highlighted by whole-brain resting-state effective connectivity analysis".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 99(2020):10. |
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