Influence of More Than 5 Years of Continuous Exposure to Antipsychotics on Cerebral Functional Connectivity of Chronic Schizophrenia | |
Miao, Qi1,8,9,10; Pu, Chengcheng1,8,9,10; Wang, Zhijiang1,8,9,10; Yan, Chao-Gan3,4,5; Shi, Chuan1,8,9,10; Cao, Qingjiu1,8,9,10; Wang, Xijin6; Cheng, Zhang1,8,9,10; Han, Xue1,8,9,10; Yang, Lei1,8,9,10 | |
刊名 | CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE |
2020-02-06 | |
页码 | 10 |
关键词 | chronic schizophrenia antipsychotics long-term resting-state functional magnetic resonance imaging functional connectivity |
ISSN号 | 0706-7437 |
DOI | 10.1177/0706743720904815 |
产权排序 | 5 |
文献子类 | article |
英文摘要 | Objective: To explore the effect of long-term antipsychotics use on the strength of functional connectivity (FC) in the brains of patients with chronic schizophrenia. Method: We collected resting-state functional magnetic resonance imaging from 15 patients with continuously treated chronic schizophrenia (TCS), 19 patients with minimally TCS (MTCS), and 20 healthy controls (HCs). Then, we evaluated and compared the whole-brain FC strength (FCS; including full-range, short-range, and long-range FCS) among patients with TCS, MTCS, and HCs. Results: Patients with TCS and MTCS showed reduced full-/short-range FC compared with the HCs. No significant differences in the whole-brain FCS (including full-range, short-range, and long-range FCS) or clinical characteristics were identified between patients with TCS and MTCS. Additionally, the FCS in the right fusiform gyrus, right inferior temporal gyrus, and right inferior occipital gyrus negatively correlated with the duration of illness and positively correlated with onset age across all patients with chronic schizophrenia. Conclusions: Regardless of the long-term use of antipsychotics, patients with chronic schizophrenia show decreased FC compared with healthy individuals. For some patients with chronic schizophrenia, the influence of long-term and minimal/short-term antipsychotic exposure on resting-state FC was similar. The decreased full- and short-range FCS in the right fusiform gyrus, right inferior temporal gyrus, and right inferior occipital gyrus may be an ongoing pathological process that is not altered by antipsychotic interventions in patients with chronic schizophrenia. Large-sample, long-term follow-up studies are still needed for further exploration. |
资助项目 | Beijing Science and Technology Commission[D171100007017002] |
WOS关键词 | UNMEDICATED PATIENTS ; GLOBAL SIGNAL ; FMRI ; PSYCHOSIS ; NETWORKS ; PHASE ; RECOGNITION ; MEDICATION ; MECHANISMS ; DOPAMINE |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | SAGE PUBLICATIONS INC |
WOS记录号 | WOS:000512246400001 |
资助机构 | Beijing Science and Technology Commission |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/30842] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Hong, Nan; Yu, Xin |
作者单位 | 1.Peking Univ, Hosp 6, Beijing, Peoples R China 2.Sixth Peoples Hosp Hebei Prov, Baoding, Peoples R China 3.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China 6.First Psychiat Hosp Harbin, Harbin, Heilongjiang, Peoples R China 7.Peking Univ, Peoples Hosp, Dept Radiol, 11 Xizhimen South St, Beijing, Peoples R China 8.Peking Univ, Inst Mental Hlth, 51 Huayuanbeilu, Beijing 100191, Peoples R China 9.Peking Univ, NHC Key Lab Mental Hlth, Beijing, Peoples R China 10.Peking Univ, Natl Clin Res Ctr Mental Hlth Disorders, Hosp 6, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Miao, Qi,Pu, Chengcheng,Wang, Zhijiang,et al. Influence of More Than 5 Years of Continuous Exposure to Antipsychotics on Cerebral Functional Connectivity of Chronic Schizophrenia[J]. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE,2020:10. |
APA | Miao, Qi.,Pu, Chengcheng.,Wang, Zhijiang.,Yan, Chao-Gan.,Shi, Chuan.,...&Yu, Xin.(2020).Influence of More Than 5 Years of Continuous Exposure to Antipsychotics on Cerebral Functional Connectivity of Chronic Schizophrenia.CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE,10. |
MLA | Miao, Qi,et al."Influence of More Than 5 Years of Continuous Exposure to Antipsychotics on Cerebral Functional Connectivity of Chronic Schizophrenia".CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE (2020):10. |
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