Waves of Change: Brain Sensitivity to Differential, not Absolute, Stimulus Intensity is Conserved Across Humans and Rats

doi:10.1093/cercor/bhaa267

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	Waves of Change: Brain Sensitivity to Differential, not Absolute, Stimulus Intensity is Conserved Across Humans and Rats
	Somervail, R.1,5; Zhang, F.3,4; Novembre, G.1; Bufacchi, R. J.1; Guo, Y.1; Crepaldi, M.2; Hu, L.3,4; Iannetti, G. D.1,5
刊名	CEREBRAL CORTEX
	2021-02-01
卷号	31 期号:2 页码:949-960
关键词	electrocorticography (ECoG) electroencephalography (EEG) behavioral relevance multispecies investigation saliency-detection
ISSN号	1047-3211
DOI	10.1093/cercor/bhaa267
通讯作者	Iannetti, G. D.(giandomenico.iannetti@iit.it)
英文摘要	Living in rapidly changing environments has shaped the mammalian brain toward high sensitivity to abrupt and intense sensory events-often signaling threats or affordances requiring swift reactions. Unsurprisingly, such events elicit a widespread electrocortical response (the vertex potential, VP), likely related to the preparation of appropriate behavioral reactions. Although the VP magnitude is largely determined by stimulus intensity, the relative contribution of the differential and absolute components of intensity remains unknown. Here, we dissociated the effects of these two components. We systematically varied the size of abrupt intensity increases embedded within continuous stimulation at different absolute intensities, while recording brain activity in humans (with scalp electroencephalography) and rats (with epidural electrocorticography). We obtained three main results. 1) VP magnitude largely depends on differential, and not absolute, stimulus intensity. This result held true, 2) for both auditory and somatosensory stimuli, indicating that sensitivity to differential intensity is supramodal, and 3) in both humans and rats, suggesting that sensitivity to abrupt intensity differentials is phylogenetically well-conserved. Altogether, the current results show that these large electrocortical responses are most sensitive to the detection of sensory changes that more likely signal the sudden appearance of novel objects or events in the environment.
资助项目	Wellcome Trust strategic award (COLL JLARAXR) ; European Research Council Consolidator Grant (PAINSTRAT) ; National Natural Science Foundation of China[31671141] ; National Natural Science Foundation of China[31822025]
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	OXFORD UNIV PRESS INC
WOS记录号	WOS:000646868100016
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/39074]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Iannetti, G. D.
作者单位	1.Ist Italiano Tecnol, Neurosci & Behav Lab, I-00161 Rome, Italy 2.Ist Italiano Tecnol, Elect Design Lab, I-16152 Genoa, Italy 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 4.CAS Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 5.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
推荐引用方式 GB/T 7714	Somervail, R.,Zhang, F.,Novembre, G.,et al. Waves of Change: Brain Sensitivity to Differential, not Absolute, Stimulus Intensity is Conserved Across Humans and Rats[J]. CEREBRAL CORTEX,2021,31(2):949-960.
APA	Somervail, R..,Zhang, F..,Novembre, G..,Bufacchi, R. J..,Guo, Y..,...&Iannetti, G. D..(2021).Waves of Change: Brain Sensitivity to Differential, not Absolute, Stimulus Intensity is Conserved Across Humans and Rats.CEREBRAL CORTEX,31(2),949-960.
MLA	Somervail, R.,et al."Waves of Change: Brain Sensitivity to Differential, not Absolute, Stimulus Intensity is Conserved Across Humans and Rats".CEREBRAL CORTEX 31.2(2021):949-960.