Sex differences in association between cognitive impairment and clinical correlates in Chinese patients with first-episode drug-naive schizophrenia | |
Zhao, Na3; Wang, Xiao Hong3; Kang, Chuan Yi3; Zheng, Yue3; Yang, Li Ying3; Guan, Tie Feng2; Bai, Yun Xia2; Wei, Ran1; Hinman, Hunter C.4; Zhang, Xiang Yang5,6 | |
刊名 | ANNALS OF GENERAL PSYCHIATRY |
2021-04-21 | |
卷号 | 20期号:1页码:9 |
关键词 | Cognition First-episode drug-naï ve patients MCCB Schizophrenia Sex difference |
DOI | 10.1186/s12991-021-00347-1 |
产权排序 | 5 |
文献子类 | 实证研究 |
英文摘要 | Background Schizophrenia is a complex mental illness with significant sex differences. Cognitive impairment is common in patients with schizophrenia, even in remission. This study was designed to examine the sex differences in the relationship between cognitive impairment and clinical correlations with first-episode drug-naive (FEDN) schizophrenia. Methods 93 FEDN patients (male/female = 45/48) and 160 controls (male/female = 74/86) were enrolled to compare the sex differences in cognitive functions measured by the MATRICS Consensus Cognitive Battery (MCCB). Positive and Negative Syndrome Scale (PANSS) and Hamilton Depression Scale (HAMD) were used to evaluate patients' clinical symptoms. We compared cognitive impairment with sociodemographic characteristics and measures of different genders, as well as group-by-sex interactions. Results Our results showed that male patients had significantly lower scores for symbol coding, digital sequence, and verbal learning than female patients, while the healthy controls showed similar sex differences. In female patients, multiple linear regression analysis confirmed that PANSS negative symptoms and general psychopathology scores, HAMD total score, and education level were independent contributors to MCCB total score. In male patients, only education was an independent contributor to MCCB total score. Conclusions These findings revealed significant sex differences in cognitive impairments and clinical symptoms in FEDN, which will be worthy of a follow-up study of schizophrenia in the future. |
资助项目 | research and innovation fund of the First Affiliated Hospital of Harbin Medical University[2020B07] |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | BMC |
WOS记录号 | WOS:000642158200001 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/39067] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiang Yang |
作者单位 | 1.Affiliated Guangji Hosp Soochow Univ, Suzhou Guangji Hosp, Dept Clin Psychol, Suzhou, Jiangsu, Peoples R China 2.First Hosp Yichun, Psychol Clin, Yichun, Heilongjiang, Peoples R China 3.First Affiliated Hosp Harbin Med Univ, Dept Psychiat, Harbin, Heilongjiang, Peoples R China 4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, Na,Wang, Xiao Hong,Kang, Chuan Yi,et al. Sex differences in association between cognitive impairment and clinical correlates in Chinese patients with first-episode drug-naive schizophrenia[J]. ANNALS OF GENERAL PSYCHIATRY,2021,20(1):9. |
APA | Zhao, Na.,Wang, Xiao Hong.,Kang, Chuan Yi.,Zheng, Yue.,Yang, Li Ying.,...&Zhang, Xiang Yang.(2021).Sex differences in association between cognitive impairment and clinical correlates in Chinese patients with first-episode drug-naive schizophrenia.ANNALS OF GENERAL PSYCHIATRY,20(1),9. |
MLA | Zhao, Na,et al."Sex differences in association between cognitive impairment and clinical correlates in Chinese patients with first-episode drug-naive schizophrenia".ANNALS OF GENERAL PSYCHIATRY 20.1(2021):9. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论