Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation | |
Jia, Xiaohua; Fan, Kelong; Zhang, Ruofei; Zhang, Dan; Zhang, Jianjun; Gao, Yuan; Zhang, Tao; Li, Wanjun; Li, Junlai; Yan, Xiyun | |
刊名 | Nanomedicine : nanotechnology, biology, and medicine |
2020-03 | |
卷号 | 27页码:102204 |
关键词 | Glioma Molecular imaging Nanoparticles Transferrin receptor 1 |
ISSN号 | 1549-9642 |
DOI | 10.1016/j.nano.2020.102204 |
产权排序 | 5 |
文献子类 | article |
英文摘要 | The vexing difficulty in distinguishing glioma from normal tissues is a major obstacle to prognosis. In an attempt to solve this problem, we used a joint strategy that combined targeted-cancer stem cells nanoparticles with precise photoacoustic and fluorescence navigation. We showed that traditional magnetic resonance imaging (MRI) did not represent the true morphology of tumors. Targeted nanoparticles specifically accumulated in the tumor area. Glioma was precisely revealed at the cellular level. Tumors could be non-invasively detected through the intact skull by fluorescence molecular imaging (FMI) and photoacoustic tomography (PAT). Moreover, PAT can be used to excise deep gliomas. Histological correlation confirmed that FMI imaging accurately delineated scattered tumor cells. The combination of optical PAT and FMI navigation fulfilled the promise of precise visual imaging in glioma detection and resection. This detection method was deeper and more intuitive than the current intraoperative pathology. |
资助项目 | National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2017YFA0700401] ; National Key Research and Development Program of China[2016YFA0100902] ; National Key Research and Development Program of China[2016YFA0201401] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81701771] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81771835] ; National Natural Science Foundation of China[31530026] ; National Natural Science Foundation of China[31900981] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YJKYYQ20180048] ; Chinese Academy of Sciences[QYZDY-SSW-SMC013] ; Chinese Academy of Sciences[QYZDJ-SSW-JSC005] ; Beijing Municipal Science & Technology Commission[Z161100002616022] ; Beijing Municipal Science & Technology Commission[Z171100000117023] ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program[19JCZDJC65300] ; Strategic Priority Research Program[XDA09030306] ; Strategic Priority Research Program[XDB29040101] ; Strategic Priority Research Program[XDPB0304] |
WOS关键词 | IMAGING BIOMARKERS ; TOMOGRAPHY ; NEUROONCOLOGY ; NANOPARTICLES ; DIAGNOSIS ; RESECTION ; ATLAS ; CELLS |
WOS研究方向 | Science & Technology - Other Topics ; Research & Experimental Medicine |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000549858200009 |
资助机构 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Beijing-Tianjin-Hebei Basic Research Cooperation Special Program ; Strategic Priority Research Program |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/31682] |
专题 | 心理研究所_健康与遗传心理学研究室 |
作者单位 | 1.CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. 2.CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; The University of Chinese Academy of Sciences, Beijing, China. 3.Center of Biomedical Analysis, Tsinghua University, Beijing, China. 4.Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. 5.Key Laboratory of Molecular Imaging of Chinese Academy of Sciences, Institute of Automation, Chinese Academy of Sciences, Beijing, China. 6.Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China. 7.Department of Pathology, Affiliated 3201 Hospital of Xi'an Jiaotong University, Hanzhong, Shaanxi, PR China. 8.Department of Ultrasound, General Hospital of People's Liberation Army, Beijing, China. Electronic address: Li_jl@yeah.net. 9.Key Laboratory of Molecular Imaging of Chinese Academy of Sciences, Institute of Automation, Chinese Academy of Sciences, Beijing, China; The University of Chinese Academy of Sciences, Beijing, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine, Beihang University, Beijing, China. 10.CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; The University of Chinese Academy of Sciences, Beijing, China. |
推荐引用方式 GB/T 7714 | Jia, Xiaohua,Fan, Kelong,Zhang, Ruofei,et al. Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation[J]. Nanomedicine : nanotechnology, biology, and medicine,2020,27:102204. |
APA | Jia, Xiaohua.,Fan, Kelong.,Zhang, Ruofei.,Zhang, Dan.,Zhang, Jianjun.,...&Yan, Xiyun.(2020).Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation.Nanomedicine : nanotechnology, biology, and medicine,27,102204. |
MLA | Jia, Xiaohua,et al."Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation".Nanomedicine : nanotechnology, biology, and medicine 27(2020):102204. |
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