Structural and functional abnormality of the putamen in children with developmental dyslexia | |
Wang, Zhao1,2,6,7; Yan, Xin6; Liu, Yanni5; Spray, Gregory J.6; Deng, Yuan4; Cao, Fan1,2,3,6 | |
刊名 | NEUROPSYCHOLOGIA |
2019-07-01 | |
卷号 | 130页码:26-37 |
关键词 | Dyslexia fMRI Phonological deficit Putamen VBM PPI |
ISSN号 | 0028-3932 |
DOI | 10.1016/j.neuropsychologia.2018.07.014 |
通讯作者 | Cao, Fan(caofan3@mail.sysu.edu.cn) |
英文摘要 | There is currently debate with regards to the role of phonological deficit in Chinese reading difficulty, even though some researchers have suggested that the deficit of phonological processing is also a signature of developmental dyslexia in Chinese, as has been found in alphabetic languages. In this study, we examined the brain mechanisms of phonological deficit in Chinese children with developmental dyslexia (DD) during an auditory rhyming judgment task. First, we examined structural differences in Chinese dyslexia by comparing gray and white matter volume in Chinese children with DD, age-matched controls (AC), and reading-matched controls (RC). Next, we examined whether the regions with an abnormal volume in DD showed deficient functional connectivity with the rest of the brain during a phonological task (i.e. auditory rhyming judgment). We found that both AC and RC had greater gray matter volume (GMV) at the left putamen and right dorsal lateral frontal cortex than DD, suggesting possible neural signatures of developmental dyslexia. Functional connectivity analysis revealed that the left putamen was more connected with the right inferior occipital gyrus (IOG) in AC and RC than in DD, suggesting that automatic orthographic involvement during spoken language processing is more salient in controls, while the left putamen was more connected with the left transverse temporal gyrus (TTG) and left insula in DD than in AC and RC, suggesting the phonological articulation-auditory feedback loop is more involved in DD. These findings suggest that the reduced left putamen might contribute to phonological deficits experienced in DD, since it showed deficient connectivity with the rest of the brain during phonological processing. |
WOS关键词 | HUMAN AUDITORY-CORTEX ; WORKING-MEMORY DEFICITS ; VOXEL-BASED MORPHOMETRY ; PHONOLOGICAL AWARENESS ; LANGUAGE IMPAIRMENT ; READING DEVELOPMENT ; FMRI CONNECTIVITY ; WORD RECOGNITION ; BASAL GANGLIA ; EARLY CHINESE |
WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology ; Psychology |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000493912900004 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/30724] |
专题 | 心理研究所_认知与发展心理学研究室 |
通讯作者 | Cao, Fan |
作者单位 | 1.Sun Yat Sen Univ, Dept Psychol, Guangzhou, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Guangdong Prov Key Lab Social Cognit Neurosci & M, Guangzhou, Guangdong, Peoples R China 3.Chinese Univ Hong Kong, Sch Humanities & Social Sci, Shenzhen, Shenzhen, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 5.Univ Michigan, Ann Arbor, MI 48109 USA 6.Michigan State Univ, Dept Commun Sci & Disorders, E Lansing, MI 48824 USA 7.Beijing Normal Univ, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Zhao,Yan, Xin,Liu, Yanni,et al. Structural and functional abnormality of the putamen in children with developmental dyslexia[J]. NEUROPSYCHOLOGIA,2019,130:26-37. |
APA | Wang, Zhao,Yan, Xin,Liu, Yanni,Spray, Gregory J.,Deng, Yuan,&Cao, Fan.(2019).Structural and functional abnormality of the putamen in children with developmental dyslexia.NEUROPSYCHOLOGIA,130,26-37. |
MLA | Wang, Zhao,et al."Structural and functional abnormality of the putamen in children with developmental dyslexia".NEUROPSYCHOLOGIA 130(2019):26-37. |
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