Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia

doi:10.1111/eip.13059

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia
	Yang, Mi 1,4,5; Gao, Shan 1; Xiong, Weisen 1,4,5; Zhang, Xiang Yang 2,3
刊名	EARLY INTERVENTION IN PSYCHIATRY
	2020-10-15
页码	9
关键词	cognitive impairment first episode schizophrenia sex difference white matter
ISSN号	1751-7885
DOI	10.1111/eip.13059
通讯作者	Zhang, Xiang Yang(zhangxy@psych.ac.cn)
英文摘要	Aim Previous evidence has suggested that schizophrenia patients may display sex differences in cognitive impairments and cognitive impairments are related to disrupted white matter (WM) microstructure. The current research aims to address the intriguing possibility for the sex-specific association between cognitive deficits and WM abnormalities in first-episode and drug-naive schizophrenia. Methods Cognitive performance on the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) was measured in 39 FEND patients (females:males = 23:16) and 30 healthy controls (females:males = 17:13), together with whole-brain WM fractional anisotropy (FA) values determined using voxel-based diffusion tensor imaging. Correlations between cognitive performance and FA values were assessed. Results Patients performed significantly worse than healthy controls in the total score and most of the subscores of MCCB. Female patients displayed better cognitive performance than male patients on the Trail Making A Test, the Hopkins Verbal Learning Test and the Spatial Span Test in the Wechsler Memory Scale. More importantly, sex-differential association between cognitive performance and FA values was found in patients, but not in healthy controls. In particular, FA values in the cerebellum were negatively correlated with the continuous performance and digital sequence scores in male patients but positively correlated with the performance on the Spatial Span Test in the Wechsler Memory Scale in female patients. Conclusions These findings suggest sex-specific neurobiological substrates involved in cognitive deficits in early-onset schizophrenia and have important implications for differentially targeted interventions between males and females.
资助项目	National Natural Science Foundation of China[61806042] ; National Natural Science Foundation of China[31600880]
WOS关键词	DIFFUSION TENSOR ; NEUROPSYCHOLOGICAL PERFORMANCE ; ONSET SCHIZOPHRENIA ; GENDER-DIFFERENCES ; CLINICAL-TRIALS ; INTEGRITY ; MICROSTRUCTURE ; 1ST-EPISODE ; BRAIN
WOS研究方向	Psychiatry
语种	英语
出版者	WILEY
WOS记录号	WOS:000577744500001
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/33049]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Zhang, Xiang Yang
作者单位	1.Univ Elect Sci & Technol China, Clin Hosp, Chengdu Brain Sci Inst, MOE Key Lab NeuroInformat, Chengdu, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Fourth Peoples Hosp Chengdu, Chengdu, Peoples R China 5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China
推荐引用方式 GB/T 7714	Yang, Mi,Gao, Shan,Xiong, Weisen,et al. Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia[J]. EARLY INTERVENTION IN PSYCHIATRY,2020:9.
APA	Yang, Mi,Gao, Shan,Xiong, Weisen,&Zhang, Xiang Yang.(2020).Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia.EARLY INTERVENTION IN PSYCHIATRY,9.
MLA	Yang, Mi,et al."Sex-differential associations between cognitive impairments and white matter abnormalities in first episode and drug-naive schizophrenia".EARLY INTERVENTION IN PSYCHIATRY (2020):9.