Sex-dependent aberrant PFC development in the adolescent offspring rats exposed to variable prenatal stress | |
Niu, Yunxia1,3,4; Wang, Tao3; Liang, Shan2; Li, Wei3; Hu, Xu3; Wu, Xiaoli3,4; Jin, Feng3 | |
刊名 | INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE |
2020-08-16 | |
页码 | 13 |
关键词 | adolescence physiological index prefrontal cortex prepulse inhibition repeated variable prenatal stress |
ISSN号 | 0736-5748 |
DOI | 10.1002/jdn.10034 |
产权排序 | 2 |
文献子类 | article |
英文摘要 | Adolescence is a remarkable period of brain development. Prenatal stress can increase the risk of various neuropsychiatric disorders. This research investigated neurochemical and behavioural changes in the offspring rats (especially adolescences) who were treated with repeated variable prenatal stress (PNS) during the third week of gestation. The study tested the concentration of brain-derived neurotrophic factor (BDNF), cluster of differentiation 68 (CD68), synaptotagmin-1(Syt-1), 5-hydroxy-tryptamine (5-HT), dopamine (DA), glucocorticoid receptors (GRs) and oestrogen receptors (ERs) in the PFC (prefrontal cortex). We also tested prepulse inhibition (PPI) of the acoustic startle reflex (ASR) (a measure of sensorimotor gating). The main results were as follows: PNS increased the BDNF and CD68 concentrations in adolescent females, and increased the Syt-1 concentration in adolescent males. The increases in BDNF/CD68 concentration (in females) and Syt-1/DA concentration (in males) with age were disturbed by PNS, and PNS changed the sex differences in CD68 concentration in adolescence and disturbed the sex differences in the Syt-1 concentration (in adolescence) and DA concentration (in adults). In conclusion, we found that PNS lead to Sex-dependent aberrant PFC development, and might accelerate the development of the adolescent PFC, and so that lessened the age difference (between adolescence and adulthood) and the sex difference. |
资助项目 | NS Bio Japan |
WOS关键词 | MEDIAL PREFRONTAL CORTEX ; NEUROTROPHIC FACTOR ; PREPULSE INHIBITION ; STARTLE REFLEX ; MESSENGER-RNA ; BRAIN ; SCHIZOPHRENIA ; PLASTICITY ; INCREASES ; ANXIETY |
WOS研究方向 | Developmental Biology ; Neurosciences & Neurology |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000562890500001 |
资助机构 | NS Bio Japan |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/32482] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Jin, Feng |
作者单位 | 1.Tianjin Univ Technol & Educ, Sch Vocat Educ, Tianjin, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, Beijing, Peoples R China 3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Niu, Yunxia,Wang, Tao,Liang, Shan,et al. Sex-dependent aberrant PFC development in the adolescent offspring rats exposed to variable prenatal stress[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2020:13. |
APA | Niu, Yunxia.,Wang, Tao.,Liang, Shan.,Li, Wei.,Hu, Xu.,...&Jin, Feng.(2020).Sex-dependent aberrant PFC development in the adolescent offspring rats exposed to variable prenatal stress.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,13. |
MLA | Niu, Yunxia,et al."Sex-dependent aberrant PFC development in the adolescent offspring rats exposed to variable prenatal stress".INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2020):13. |
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