Direct 3D Printed Biomimetic Scaffolds Based on Hydrogel Microparticles for Cell Spheroid Growth

doi:10.1002/adfm.201910573

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2020专题

	Direct 3D Printed Biomimetic Scaffolds Based on Hydrogel Microparticles for Cell Spheroid Growth
	Zhang, Hua ; Cong, Yang ; Osi, Amarachi Rosemary ; Zhou, Yang ; Huang, Fangcheng ; Zaccaria, Remo P.; Chen, Jing ; Wang, Rong ; Fu, Jun
刊名	ADVANCED FUNCTIONAL MATERIALS
	2020
卷号	30 期号:13
关键词	STEM-CELLS DIFFERENTIATION ANGIOGENESIS CONSTRUCTS CHITOSAN
DOI	10.1002/adfm.201910573
英文摘要	Biocompatible hydrogel inks with shear-thinning, appropriate yield strength, and fast self-healing are desired for 3D bioprinting. However, the lack of ideal 3D bioprinting inks with outstanding printability and high structural fidelity, as well as cell-compatibility, has hindered the progress of extrusion-based 3D bioprinting for tissue engineering. In this study, novel self-healable pre-cross-linked hydrogel microparticles (pcH mu Ps) of chitosan methacrylate (CHMA) and polyvinyl alcohol (PVA) hybrid hydrogels are developed and used as bioinks for extrusion-based 3D printing of scaffolds with high fidelity and biocompatibility. The pcH mu Ps display excellent shear thinning when injected through a syringe and subsequently self-heal into gels as shear forces are removed. Numerical simulations indicate that the pcH mu Ps experience a plug flow in the nozzle with minimal disturbance, which favors a steady and continuous printing. Moreover, the pcH mu Ps show a self-supportive yield strength (540 Pa), which is critical for the fidelity of printed constructs. A series of biomimetic constructs with very high aspect ratio and delicate fine structures are directly printed by using the pcH mu P ink. The 3D printed scaffolds support the growth of bone-marrow-derived mesenchymal stem cells and formation of cell spheroids, which are most important for tissue engineering.
学科主题	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/19984]
专题	2020专题
作者单位	1.Fu, J (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Peoples R China. 2.Fu, J (corresponding author), Sun Yat Sen Univ, Sch Mat Sci & Engn, Guangzhou 510275, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, Hua,Cong, Yang,Osi, Amarachi Rosemary,et al. Direct 3D Printed Biomimetic Scaffolds Based on Hydrogel Microparticles for Cell Spheroid Growth[J]. ADVANCED FUNCTIONAL MATERIALS,2020,30(13).
APA	Zhang, Hua.,Cong, Yang.,Osi, Amarachi Rosemary.,Zhou, Yang.,Huang, Fangcheng.,...&Fu, Jun.(2020).Direct 3D Printed Biomimetic Scaffolds Based on Hydrogel Microparticles for Cell Spheroid Growth.ADVANCED FUNCTIONAL MATERIALS,30(13).
MLA	Zhang, Hua,et al."Direct 3D Printed Biomimetic Scaffolds Based on Hydrogel Microparticles for Cell Spheroid Growth".ADVANCED FUNCTIONAL MATERIALS 30.13(2020).