Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields

doi:10.1039/d0ra01458c

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2020专题

	Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields
	Wu, Tingting ; Zhang, Qian ; Hu, Huiping ; Yang, Fang ; Li, Ke ; Zhang, Yu ; Shi, Chen
刊名	RSC ADVANCES
	2020
卷号	10 期号:25 页码:14471-14481
关键词	NANOPARTICLES TETRANDRINE INHIBITION RESISTANCE APOPTOSIS PATHWAYS RELEASE IRON
DOI	10.1039/d0ra01458c
英文摘要	Magnetic nanoparticles have been widely used in cancer treatment for their potential magnetic functions and synergistic antitumor effect with therapeutic agents. In this work, we developed a polymeric nanosystem by co-loading the natural anticancer drug tetrandrine and superparamagnetic iron oxide nanoparticles for cancer combinatorial therapy. The nanosystem possessed regular morphology and superior magnetic properties. Under the action of external rotating permanent magnets, the nanosystem could transfer a rotational motion to damage the cellular membrane, which would result in the increased permeabilization of the cell membrane and damage to lysosomes. Hence, the specific characteristics of the magnetic nanosystem induced potent cytotoxicity and enhanced the effect of the tetrandrine-induced cell apoptosis. With further exploration, we found that this nanoplatform caused cell death via a lysosomal-mitochondrial apoptotic pathway with the upregulation of proapoptotic proteins (Cathepsin B, Smac/Diablo, Cytochrome C, and Caspase 3) and the down-regulation of antiapoptotic proteins (Bcl-2 and XIAP). These findings demonstrate that the combination therapy mediated by co-loaded magnetic nanosystems can be used for a multi-therapeutic effect against tumors in biomedical applications.
学科主题	Chemistry
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/19788]
专题	2020专题
作者单位	1.Shi, C (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan, Peoples R China. 2.Shi, C (corresponding author), Hubei Prov Clin Res Ctr Precis Med Crit Illness, Wuhan 430022, Peoples R China.
推荐引用方式 GB/T 7714	Wu, Tingting,Zhang, Qian,Hu, Huiping,et al. Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields[J]. RSC ADVANCES,2020,10(25):14471-14481.
APA	Wu, Tingting.,Zhang, Qian.,Hu, Huiping.,Yang, Fang.,Li, Ke.,...&Shi, Chen.(2020).Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields.RSC ADVANCES,10(25),14471-14481.
MLA	Wu, Tingting,et al."Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields".RSC ADVANCES 10.25(2020):14471-14481.