Greenness exposure and all-cause mortality during multi-drug resistant tuberculosis treatment: A population-based cohort study | |
Ge, Erjia1; Gao, Jianhui2; Ren, Zhoupeng3; Liu, Xin4; Luo, Ming5; Zhong, Jieming6; Fei, Fangrong6; Chen, Bin7; Wang, Xiaomeng7; Wei, Xiaolin8 | |
刊名 | SCIENCE OF THE TOTAL ENVIRONMENT |
2021-06-01 | |
卷号 | 771页码:8 |
关键词 | Multidrug resistant tuberculosis All-cause mortality Greenness exposure PM2.5 |
ISSN号 | 0048-9697 |
DOI | 10.1016/j.scitotenv.2021.145422 |
通讯作者 | Wang, Xiaomeng(xmwang@cdc.zj.cn) ; Wei, Xiaolin(xiaolin.wei@utoronto.ca) ; Peng, Ying(ypeng@cdc.zj.cn) |
英文摘要 | Background: Living closer to greenness were thought to benefit various health outcomes. We aimed to assess the association between residential greenness and mortality among patients undergoing multidrug resistant tuberculosis (MDR-TB) treatment. Methods: We enrolled all local MDR-TB patients reported in Zhejiang, China from 2009 to 2017 and followed them throughout the treatment. We calculated the contemporaneous normalized difference vegetation index (NDVI) in the 250 and 500 m radius around patient's residence. Cox proportional hazards regression models with time-varying NDVI were used to assess the impact of greenness exposure on all-cause mortality during MDR-TB treatment, adjusting for potential individual and contextual covariates. Results: We ascertained 1,621 activeMDR-TB cases, which contributed 3036 person-years at risk with an average follow-up of 684 days (s.d. 149 days) per patient. Among them, there were 163 deaths during follow-up, representing a crude mortality rate of 537 deaths per 10,000 person-years. Patients exposed to the second quintile (Q2) of greenness within the 500 m buffer had around 64% reducedmortality risk over the lowest quintile of greennesswith hazard ratio (HR) = 0.364 (95% CI: 0.109-1.22). In lower nighttime light (NTL) areas, the hazard ratios (HR) per quintile increase in NDVI within the 500 m buffer were Q2: 0.35 (95% CI: 0.10-1.18), Q3: 0.24 (95% CI: 0.09-0.66), Q4: 0.26 (95% CI: 0.10-0.69), and Q5: 0.26 (95% CI: 0.10-0.71) relevant to the lowest quintile Q1, with a trend of p-value <= 0.01. Patientswho were female, younger (<60 years), resided in urban areas, or had high PM2.5 (i.e. particles with diagram <= 2.5 mu m) exposure were more likely to benefit from greenness exposure. Associations were neither observed with NDVI in the 250 m buffer nor for patients living in higher NTL areas. There was a non-linear exposure-response relationship between greenness and deaths with p-value <= 0.05. Conclusion: Increasing greenness exposure along with medical treatment reduces all-cause mortality among patients living in lower NTL areas. (C) 2021 Elsevier B.V. All rights reserved. |
资助项目 | Zhejiang Provincial Medical and Health Project[2019RC135] ; State Key Laboratory of Health Technology Assessment, Fudan University[FHTA2019-05] ; National Nature Science Foundation of China[71640019] |
WOS研究方向 | Environmental Sciences & Ecology |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000627895900127 |
资助机构 | Zhejiang Provincial Medical and Health Project ; State Key Laboratory of Health Technology Assessment, Fudan University ; National Nature Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.igsnrr.ac.cn/handle/311030/161924] |
专题 | 中国科学院地理科学与资源研究所 |
通讯作者 | Wang, Xiaomeng; Wei, Xiaolin; Peng, Ying |
作者单位 | 1.Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada 2.Univ Toronto, Dalla Lana Sch Publ Hlth, Div Biostat, Toronto, ON, Canada 3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing, Peoples R China 4.Southwest Petr Univ, Sch Geosci & Technol, Chengdu, Sichuan, Peoples R China 5.Sun Yat Sen Univ, Sechool Geog & Planning, Guangzhou, Guangdong, Peoples R China 6.Zhejiang Prov Ctr Dis Control & Prevent, Div Chron Dis, Hangzhou, Zhejiang, Peoples R China 7.Zhejiang Prov Ctr Dis Control & Prevent, Div TB, 3399 Bin Sheng Rd, Hangzhou, Zhejiang, Peoples R China 8.Univ Toronto, Dalla Lana Sch Publ Hlth, Inst Hlth Policy & Evaluat, Div Clin Publ Hlth, Toronto, ON, Canada |
推荐引用方式 GB/T 7714 | Ge, Erjia,Gao, Jianhui,Ren, Zhoupeng,et al. Greenness exposure and all-cause mortality during multi-drug resistant tuberculosis treatment: A population-based cohort study[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,771:8. |
APA | Ge, Erjia.,Gao, Jianhui.,Ren, Zhoupeng.,Liu, Xin.,Luo, Ming.,...&Peng, Ying.(2021).Greenness exposure and all-cause mortality during multi-drug resistant tuberculosis treatment: A population-based cohort study.SCIENCE OF THE TOTAL ENVIRONMENT,771,8. |
MLA | Ge, Erjia,et al."Greenness exposure and all-cause mortality during multi-drug resistant tuberculosis treatment: A population-based cohort study".SCIENCE OF THE TOTAL ENVIRONMENT 771(2021):8. |
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