The mediated role of complement C3 in PM2.5 exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China

doi:10.1007/s11356-019-06487-y

	The mediated role of complement C3 in PM2.5 exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China
	Tong, Yuanren 1,2; Pei, Lu 1,2; Luo, Kai 1,2; Zhao, Meiduo 1,2; Xu, Jing 1,2; Li, Ang 1,2; Li, Runkui 3,4; Yang, Mingan 5; Xu, Qun 1
刊名	ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
	2019-11-01
卷号	26 期号:33 页码:34479-34486
关键词	Diabetes mellitus T2DMpopulation PM2.5 C3 Mediation effects
ISSN号	0944-1344
DOI	10.1007/s11356-019-06487-y
通讯作者	Xu, Qun(xuqun@ibms.cams.cn)
英文摘要	Diabetes mellitus (DM) is a common chronic disease worldwide. Ambient air pollution has long been proven to be associated with type 2 diabetes mellitus (T2DM) progression, but the underlying mechanism is not clear yet. In addition, previous studies mainly focused on the prevention of healthy people against the incidence of T2DM. We designed a panel study including two follow-ups and enrolled 39 patients with T2DM living in Beijing. Linear mixed model was fitted to assess the association between two pairs of variables (ambient air pollution exposure and C3 levels, ambient air pollution exposures and T2DM index). Mediation analysis of C3 between ambient air pollution exposure and indicators of T2DM progression was conducted. We found that PM2.5 exposures is are negatively associated with serum complement C3. Given that C3 might act as a protector of pancreas beta cell, PM2.5 exposures could accelerate disease in T2DM populations. No mediation effects were found. This study reveals that exposures to PM2.5 can cause progression of diseases among T2DM populations.
资助项目	China Medical Board[15-230] ; Gong-Yi Program of Chinese Ministry of Environmental Protection[200909016] ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences[2017-I2M-1-009] ; National Natural Science Foundation of China[41771435] ; China Scholarship Council[201704910297] ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences[Y88Q0300YD]
WOS关键词	INSULIN-RESISTANCE ; AIR-POLLUTION
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	SPRINGER HEIDELBERG
WOS记录号	WOS:000507273700072
资助机构	China Medical Board ; Gong-Yi Program of Chinese Ministry of Environmental Protection ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences ; National Natural Science Foundation of China ; China Scholarship Council ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/131281]
专题	中国科学院地理科学与资源研究所
通讯作者	Xu, Qun
作者单位	1.Chinese Acad Med Sci, Dept Epidemiol & Biostat, Inst Basic Med Sci, Sch Basic Med,Peking Union Med Coll, Beijing 100005, Peoples R China 2.Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing 100005, Peoples R China 3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China 5.San Diego State Univ, Grad Sch Publ Hlth, Div Biostat & Epidemiol, San Diego, CA 92182 USA
推荐引用方式 GB/T 7714	Tong, Yuanren,Pei, Lu,Luo, Kai,et al. The mediated role of complement C3 in PM2.5 exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2019,26(33):34479-34486.
APA	Tong, Yuanren.,Pei, Lu.,Luo, Kai.,Zhao, Meiduo.,Xu, Jing.,...&Xu, Qun.(2019).The mediated role of complement C3 in PM2.5 exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,26(33),34479-34486.
MLA	Tong, Yuanren,et al."The mediated role of complement C3 in PM2.5 exposure and type 2 diabetes mellitus: an elderly panel study in Beijing, China".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 26.33(2019):34479-34486.