Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos

doi:10.1039/d0en00464b

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos
	Ji, Yunxia 1; Wang, Chuyu 1; Wang, Yunqing 1,3; Fu, Longwen 1; Man, Mingsan 1; Chen, Lingxin 1,2,3
刊名	ENVIRONMENTAL SCIENCE-NANO
	2020-08-01
卷号	7 期号:8 页码:2313-2324
ISSN号	2051-8153
DOI	10.1039/d0en00464b
通讯作者	Wang, Yunqing(yqwang@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	Nanoplastics (NPs) as pollutants in aquatic environments and as a public health issue due to their accumulation in food chains are of increasing concern. However, previous studies have employed mainly commercial, chemically synthesized polystyrene model particles. Commercial NPs made of polyethylene terephthalate (PET), which is widely used in drinking bottles and packaging, are rarely manufactured, and thus have not been frequently studied in the laboratory. This seriously limits our understanding of their real environmental and biological effects. Herein, we employ a simple method for producing PET NPs directly from plastic bottles, preserving the PET chemical properties, and mimicking the mechanical breakdown process of plastics in nature. Using developing zebrafish embryos as an animal model, we investigate the bioaccumulation andin vivotoxicity of the produced PET NPs, which have diameter sizes of 20, 60-80, and 800 nm and are capped by two dispersing agents,i.e., BSA and SDS. This study demonstrates the size-dependent distribution and the size- and concentration-dependent toxicity of PET NPs in terms of hatching rate, heart rate, and ROS generation. It also reveals that the PETBSANP treatment groups exhibited higher-level abnormalities in heart rate and more severe oxidative damage than the PETSDSNP treatment groups. Taken together, this work proposes a novel mechanical preparation protocol for PET NPs and provides evidence relating to the toxicity of environmentally relevant NPs towards aquatic organisms.
资助项目	National Natural Science Foundation of China[81573393] ; National Natural Science Foundation of China[21976209] ; Science and Technology Development Plan of Shandong Province of China[2019GSF108047] ; Youth Innovation Promotion Association CAS[2017256] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201662] ; Taishan Scholar Project Special Funding[ts20190962] ; Technical Innovation Project of Instrument Function Development of the Chinese Academy of Sciences
WOS关键词	CONFORMATIONAL-CHANGES ; SILICA NANOPARTICLES ; PROTEIN ADSORPTION ; DANIO-RERIO ; PARTICLES ; MICROPLASTICS ; TOXICITY ; INGESTION ; SILVER ; DAMAGE
WOS研究方向	Chemistry ; Environmental Sciences & Ecology ; Science & Technology - Other Topics
语种	英语
WOS记录号	WOS:000558930600007
资助机构	National Natural Science Foundation of China ; Science and Technology Development Plan of Shandong Province of China ; Youth Innovation Promotion Association CAS ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Technical Innovation Project of Instrument Function Development of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/28561]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室烟台海岸带研究所_近岸生态与环境实验室烟台海岸带研究所_山东省海岸带环境工程技术研究中心
通讯作者	Wang, Yunqing; Chen, Lingxin
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Ji, Yunxia,Wang, Chuyu,Wang, Yunqing,et al. Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos[J]. ENVIRONMENTAL SCIENCE-NANO,2020,7(8):2313-2324.
APA	Ji, Yunxia,Wang, Chuyu,Wang, Yunqing,Fu, Longwen,Man, Mingsan,&Chen, Lingxin.(2020).Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos.ENVIRONMENTAL SCIENCE-NANO,7(8),2313-2324.
MLA	Ji, Yunxia,et al."Realistic polyethylene terephthalate nanoplastics and the size- and surface coating-dependent toxicological impacts on zebrafish embryos".ENVIRONMENTAL SCIENCE-NANO 7.8(2020):2313-2324.