A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells

doi:10.1016/j.bbrc.2020.09.049

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells
	Pu, Yang 1,2; Wei, Mengjiao 1; Witkowski, Andrzej 3; Krzywda, Marta 3; Wang, Yinchu 4; Li, Wenjun 4
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2020-12-10
卷号	533 期号:3 页码:573-579
关键词	Biofunctional biosilica C-phycocyanin Phycocyanobilin Enhanced photodynamic effect Nanocarriers
ISSN号	0006-291X
DOI	10.1016/j.bbrc.2020.09.049
通讯作者	Pu, Yang(ypu@ldu.edu.cn) ; Li, Wenjun(wjli@yic.ac.cn)
英文摘要	Intricate mesoporous biosilica has many biomedical applications as a nanocarrier. However, its potential use in photodynamic therapy (PDT) has received little attention. This work reports the first fabrication of bio-engineered materials by covalently conjugating C-phycocyanin (C-PC), a natural photosensitizer, to biosilica for the PDT of tumor-associated macrophages. The resulting hybrid material showed outstanding photodynamic activity under 620 nm laser irradiation. Furthermore, it enhanced the relatively weak photodynamic effect of C-PC. This study also explored methods of biofunctionalizing biosilica for cancer phototherapy, a new pharmacological application of non-toxic C-PC. (C) 2020 Elsevier Inc. All rights reserved.
资助项目	National Natural Science Foundation of China[41906109] ; Key Research and Development Program of Yantai[2019XDHZ101] ; Key Research and Development Program of Yantai[2020MSGY084] ; TEAM-NET programme of the Foundation for Polish Science ; European Union under the European Regional Development Fund
WOS关键词	APOPTOSIS ; DIATOMS ; PHYCOBILIPROTEINS ; PHYCOBILISOMES ; ANTIOXIDANT ; CYCLE ; DRUG
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
WOS记录号	WOS:000588268300046
资助机构	National Natural Science Foundation of China ; Key Research and Development Program of Yantai ; TEAM-NET programme of the Foundation for Polish Science ; European Union under the European Regional Development Fund
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/28320]
专题	海岸带生物学与生物资源利用重点实验室烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室中国科学院烟台海岸带研究所
通讯作者	Pu, Yang; Li, Wenjun
作者单位	1.Ludong Univ, Sch Agr, Yantai 264025, Peoples R China 2.Ludong Univ, Bionanotechnol Res Inst, Yantai 264025, Peoples R China 3.Univ Szczecin, Inst Marine & Environm Sci, Szczecin, Poland 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Pu, Yang,Wei, Mengjiao,Witkowski, Andrzej,et al. A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2020,533(3):573-579.
APA	Pu, Yang,Wei, Mengjiao,Witkowski, Andrzej,Krzywda, Marta,Wang, Yinchu,&Li, Wenjun.(2020).A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,533(3),573-579.
MLA	Pu, Yang,et al."A hybrid biomaterial of biosilica and C-phycocyanin for enhanced photodynamic effect towards tumor cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533.3(2020):573-579.