Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

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	Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys
	Chen G 1; Qian H 1; Starz T*2; Sun HT 3; Garcia B 3; Wang XM 1; Wise Y 1; Liu YQ 1; Xiang Y ; Copeman L 4
刊名	NATURE MEDICINE
	2005
卷号	11 期号:12 页码:1295-1298
ISSN号	1078-8956
英文摘要	We transplanted kidneys from alpha 1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GaIT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GaIT-KO pigs to humans.
URL标识	查看原文
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/2685]
专题	昆明动物研究所_其他
通讯作者	mangantl@upmc.edu
作者单位	1.Univ Western Ontario, Dept Surg, London, ON N6A 5C1, Canada 2.Univ Pittsburgh, Ctr Med, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15213 USA 3.Univ Western Ontario, Dept Pathol, London, ON N6A 5A5, Canada 4.Robarts Res Inst, Transplantat Grp, London, ON N6A 5C1, Canada 5.Univ Western Ontario, Dept Med, London, ON N6A 5A5, Canada 6.London Hlth Sci Ctr, Lawson Hlth Res Inst, London, ON N6A 5A5, Canada 7.London Hlth Sci Ctr, Multi Organ Transplant Program, London, ON N6A 5A5, Canada 8.Revivcor Inc, Blacksburg, VA 24060 USA 9.Chinese Acad Sci, Kunming Inst Zool, Anim Toxicol Lab, Kunming, Peoples R China 10.Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6A 5C1, Canada
推荐引用方式 GB/T 7714	Chen G,Qian H,Starz T*,et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys[J]. NATURE MEDICINE,2005,11(12):1295-1298.
APA	Chen G.,Qian H.,Starz T*.,Sun HT.,Garcia B.,...&mangantl@upmc.edu.(2005).Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.NATURE MEDICINE,11(12),1295-1298.
MLA	Chen G,et al."Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys".NATURE MEDICINE 11.12(2005):1295-1298.