Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives

doi:10.1002/star.201800026

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物资源高效利用研究与发展中心

	Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives
	Luan, Fang ; Wei, Lijie ; Zhang, Jingjing ; Tan, Wenqiang ; Chen, Yuan ; Wang, Ping ; Dong, Fang ; Li, Qing ; Guo, Zhanyong
刊名	STARCH-STARKE
	2018-11
卷号	70 期号:11-12 页码:1800026
关键词	antifungal activity N-diquaternized chitin N-quaternized chitin quaternary ammonium salt
ISSN号	0038-9056
DOI	10.1002/star.201800026
产权排序	[Luan, Fang ; Wei, Lijie ; Zhang, Jingjing ; Tan, Wenqiang ; Chen, Yuan ; Dong, Fang ; Li, Qing ; Guo, Zhanyong] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China ; [Luan, Fang ; Wei, Lijie ; Zhang, Jingjing ; Tan, Wenqiang ; Chen, Yuan ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Wang, Ping] Binzhou Med Univ Hosp, Dept Infect Dis, Binzhou 256603, Peoples R China
文献子类	Article
英文摘要	To improve the bioactivity of chitin (CT), novel N-quaternized (QCT), and N-diquaternized (DQCT) CT derivatives are synthesized through a series of reactions from CT. The derivatives are characterized using elemental analysis, FTIR, and C-13 NMR. In addition, the inhibitory effects of the compounds against three fungi (B. cinerea, F. oxysporum, and P. asparagi) are tested. The inhibitory indices of CT, QCT, and DQCT are 12-15%, 63-73%, and 74-89%, respectively, at 1.0 mg mL(-1). The antifungal activities are in the order of DQCT > QCT > CT, which correlated with the number of quaternized groups. Based on these results, it is concluded that the antifungal activity of CT is improved by the introduction of quaternized groups on CT backbone.
WOS关键词	FACILE CHEMICAL-MODIFICATIONS ; CHITOSAN DERIVATIVES ; ANTIBACTERIAL ACTIVITY ; ANTIOXIDANT ACTIVITIES ; ANTIMICROBIAL ACTIVITY ; BETA-CHITIN ; IN-VITRO ; EXTRACTION ; PRECURSORS
WOS研究方向	Food Science & Technology
语种	英语
WOS记录号	WOS:000449763300030
资助机构	National Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of China [ZR2017BD015] ; Yantai Science and Technology Development Plan [2015ZH078, 2015418022-3] ; Technology Research Funds Projects of Ocean [2015418022-3]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24564]
专题	海岸带生物资源高效利用研究与发展中心烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室烟台海岸带研究所_污染过程与控制实验室
作者单位	1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Binzhou Med Univ Hosp, Dept Infect Dis, Binzhou 256603, Peoples R China
推荐引用方式 GB/T 7714	Luan, Fang,Wei, Lijie,Zhang, Jingjing,et al. Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives[J]. STARCH-STARKE,2018,70(11-12):1800026.
APA	Luan, Fang.,Wei, Lijie.,Zhang, Jingjing.,Tan, Wenqiang.,Chen, Yuan.,...&Guo, Zhanyong.(2018).Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives.STARCH-STARKE,70(11-12),1800026.
MLA	Luan, Fang,et al."Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives".STARCH-STARKE 70.11-12(2018):1800026.