The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice | |
Xie, YY; Li, WJ; Lu, CY; Zhu, LM; Qin, S; Du, ZN | |
刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY |
2019-10 | |
卷号 | 103期号:20页码:8559-8569 |
关键词 | Phycocyanin Pulmonary fibrosis Cytokines Intestinal microbiome |
ISSN号 | 0175-7598 |
DOI | 10.1007/s00253-019-10018-7 |
产权排序 | [Xie, Yuanyuan ; Li, Wenjun ; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China ; [Xie, Yuanyuan ; Du, Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China ; [Xie, Yuanyuan ; Li, Wenjun ; Qin, Song] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China ; [Lu, Chenyang] Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China ; [Zhu, Limeng] Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China |
文献子类 | Article |
英文摘要 | Phycocyanin (PC) is a light-harvesting protein isolated from Spirulina and has health benefits for a range of diseases including pulmonary fibrosis (PF). In this study, a bleomycin-induced pulmonary fibrosis model was used to determine whether PC attenuates PF and modulates the intestinal microbiota. The results showed that PC intervention attenuated the pulmonary fibrosis, demonstrated by hematoxylin-eosin staining (HE), Masson's trichrome staining, and lung dry-wet weight ratio, and PC significantly inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and lipopolysaccharide (LPS). Additionally, intestinal microbiota analysis revealed that PC intervention significantly increased the bacterial diversity and richness. Correlation analysis indicated that 9 families and 17 genes were significantly associated with at least 1 physiological index. And PC intervention significantly decreased the bacteria which is related to inflammation and dramatically increased the SCFAs-producing bacteria and probiotics. These data indicated that PC can decrease the pro-inflammatory cytokines and regulate the intestinal microbiota in BLM-induced PF mice. |
WOS关键词 | C-PHYCOCYANIN ; HELICOBACTER-PYLORI ; ANTIOXIDANT ; SPIRULINA |
WOS研究方向 | Biotechnology & Applied Microbiology |
语种 | 英语 |
WOS记录号 | WOS:000491439700024 |
资助机构 | National Key Research and Development Program of China [2018YFD0901102] ; Key Research and Development Program of Yantai [2019XDHZ101] |
内容类型 | 期刊论文 |
源URL | [http://ir.yic.ac.cn/handle/133337/24843] |
专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China; 4.Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China; 5.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China |
推荐引用方式 GB/T 7714 | Xie, YY,Li, WJ,Lu, CY,et al. The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2019,103(20):8559-8569. |
APA | Xie, YY,Li, WJ,Lu, CY,Zhu, LM,Qin, S,&Du, ZN.(2019).The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,103(20),8559-8569. |
MLA | Xie, YY,et al."The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103.20(2019):8559-8569. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论