Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels

doi:10.1016/j.ijbiomac.2018.05.200

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源利用所重点实验室

	Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels
	Wang, Mingchao ; Li, Jie ; Li, Wenjun ; Du, Zhenning ; Qin, Song
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2018-10-15
卷号	118 期号:A 页码:41-48
关键词	Collagen Poly (vinyl alcohol) Double-network Hydrogel Self-crosslink
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2018.05.200
产权排序	[Wang, Mingchao ; Du, Zhenning] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Minist Educ, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China ; [Li, Jie ; Li, Wenjun ; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
文献子类	Article
英文摘要	Hydrogels prepared by conventional methods show poor performance in many aspects. Many double network (DN) hydrogels prepared by crosslinking agents have disadvantages such as toxicity. In this work, we prepared novel DN hydrogels with fish-originated collagen (Col) and poly (vinyl alcohol) (PVA), in which self-assembly of collagen and self-crosslinking of PVA were achieved. Infrared spectra indicated the existence of double network with chemical interactions between Col and PVA. X-ray diffraction (XRD) patterns showed that characteristic peak of freeze-thaw PVA in DN hydrogel was retained. Scanning electron microscope (SEM) images before and after degradation and swelling property tests indicated that the morphology of the hydrogel was a compact meshwork, which is consistent with the high water-retention rate. The degradation rate of the DN hydrogels was controlled by the ratio of Col and PVA. Compared with a pure collagen hydrogels, the stress of DN hydrogels was greatly enhanced from 6 to 33 kPa at a strain of 40%. This study indicates that DN hydrogels prepared by Col and PVA are an ideal biomaterial for tissue engineering. (C) 2018 Published by Elsevier B.V.
WOS关键词	MECHANICAL-PROPERTIES ; COLLAGEN HYDROGELS ; BONE REGENERATION ; ALCOHOL HYDROGEL ; HYBRID HYDROGELS ; SKIN COLLAGEN ; FISH COLLAGEN ; I COLLAGEN ; GELLAN GUM ; CHITOSAN
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
语种	英语
WOS记录号	WOS:000445170200006
资助机构	Yantai Innovative Marine Medical Materials Industry Incubation Aggregation Innovation and Demonstration Project [YHCX-SW-Y-201701] ; National Key Research and Development Program China [2016YFF0202304] ; [KFZD-SW-218]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24549]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Minist Educ, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat, Yantai 264005, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Wang, Mingchao,Li, Jie,Li, Wenjun,et al. Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,118(A):41-48.
APA	Wang, Mingchao,Li, Jie,Li, Wenjun,Du, Zhenning,&Qin, Song.(2018).Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,118(A),41-48.
MLA	Wang, Mingchao,et al."Preparation and characterization of novel poly (vinyl alcohol)/collagen double-network hydrogels".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 118.A(2018):41-48.