Preparation and Characterization of Quaternized Chitosan Derivatives and Assessment of Their Antioxidant Activity

doi:10.3390/molecules23030516

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源利用所重点实验室

	Preparation and Characterization of Quaternized Chitosan Derivatives and Assessment of Their Antioxidant Activity
	Luan, Fang ; Wei, Lijie ; Zhang, Jingjing ; Tan, Wenqiang ; Chen, Yuan ; Dong, Fang ; Li, Qing ; Guo, Zhanyong
刊名	MOLECULES
	2018-03
卷号	23 期号:3 页码:516
关键词	cationic chitosan derivatives quaternized chitosan double quaternized chitosan antioxidant ability
ISSN号	1420-3049
DOI	10.3390/molecules23030516
产权排序	[Luan, Fang ; Wei, Lijie ; Zhang, Jingjing ; Tan, Wenqiang ; Chen, Yuan ; Dong, Fang ; Li, Qing ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China ; [Luan, Fang ; Wei, Lijie ; Zhang, Jingjing ; Tan, Wenqiang ; Chen, Yuan ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
文献子类	Article
英文摘要	Chitosan (CS) is an abundant and renewable polysaccharide that is reported to exhibit a great variety of beneficial properties. However, the poor solubility of chitosan in water limits its applications. In this paper, we successfully synthesized single N-quaternized (QCS) and double N-diquaternized (DQCS) chitosan derivatives, and the resulting quaternized materials were water-soluble. The degree of quaternization (DQ) of QCS and DQCS was 0.8 and 1.3, respectively. These derivatives were characterized by FTIR, H-1 NMR, C-13 NMR, TGA, and SEM. Moreover, the antioxidant activity of the chitosan was evaluated by free radical scavenging ability (against DPPH-radical, hydroxyl-radical, and superoxide-radical) and ferric reducing power. Our results suggested that the antioxidant abilities were in the order of DQCS > QCS > CS, which was consistent with the number of quaternized groups. These data demonstrate that the number of quaternized groups of chitosan derivatives contributes to their antioxidant activity. Therefore, DQCS, with a higher number of quaternized groups and higher positive charge density, is endowed with high antioxidant activity, and can be used as a candidate material in food and pharmaceutical industries.
WOS关键词	ANTIBACTERIAL ACTIVITY ; CHEMICAL-MODIFICATIONS ; SCAVENGING ACTIVITY ; TRIMETHYL CHITOSAN ; AMMONIUM CHITOSAN ; CHITIN ; EXTRACTION ; HYDROGELS ; CHLORIDE
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
语种	英语
WOS记录号	WOS:000428514100007
资助机构	Natural Science Foundation of China [41576156] ; Shandong Province Science and Technology Development Plan [2015GSF121045] ; Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24496]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室烟台海岸带研究所_污染过程与控制实验室海岸带生物资源高效利用研究与发展中心
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Luan, Fang,Wei, Lijie,Zhang, Jingjing,et al. Preparation and Characterization of Quaternized Chitosan Derivatives and Assessment of Their Antioxidant Activity[J]. MOLECULES,2018,23(3):516.
APA	Luan, Fang.,Wei, Lijie.,Zhang, Jingjing.,Tan, Wenqiang.,Chen, Yuan.,...&Guo, Zhanyong.(2018).Preparation and Characterization of Quaternized Chitosan Derivatives and Assessment of Their Antioxidant Activity.MOLECULES,23(3),516.
MLA	Luan, Fang,et al."Preparation and Characterization of Quaternized Chitosan Derivatives and Assessment of Their Antioxidant Activity".MOLECULES 23.3(2018):516.