藻蓝蛋白对辐射致小鼠氧化损伤的保护作用

doi:DOI: 10.11889/j.0253-3219.2018.hjs.41.010302

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源利用所重点实验室

	藻蓝蛋白对辐射致小鼠氧化损伤的保护作用
	刘琪 ; 李文军 ; 陆丽娜 ; 谢园园 ; 王明超 ; 秦松 ; 杜振宁
刊名	核技术
	2018-01-10
卷号	41 期号:1 页码:10302-
关键词	Phycocyanin X-ray irradiation Antioxidant system 藻蓝蛋白 X射线辐射抗氧化系统
ISSN号	0253-3219
DOI	DOI: 10.11889/j.0253-3219.2018.hjs.41.010302
其他题名	Protective effect of phycocyanin against oxidative damage induced by radiation
产权排序	(1)烟台大学药学院 ; (2)中国科学院烟台海岸带研究所 ; (3)兰州大学核科学与技术学院
文献子类	Article
英文摘要	[Background] Phycocyanin (PC) is a pigment protein present in cyanobacteria, cryptophyta, etc. [Purpose] This study aims at the protective effect of phycocyanin on oxidative damage induced by irradiation by establishing injury mouse model by X-ray irradiation. [Methods] 72 C57 BL/6 male mice were randomly divided into normal control group, irradiation model group, PC pretreatment group and positive control group. The mice were continuously fed for 7 d. On the 8th day of intragastric administration, except for the normal control group, the rest of the mice were subjected to total body irradiation to a dose of 6 Gy for the preparation of radiation damage model. The plasma and tissues were collected at 1 d, 3 d and 7 d after irradiation, and the activities of antioxidant enzymes in plasma and liver were measured. The content of reactive oxygen species (ROS) in liver tissue was detected by dihydroethidium (DHE) staining. [Results] Phycocyanin increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in the plasma of mice after irradiation, and increased the activity of SOD (p<0.05), decreased malondialdehyde (MDA) content (p<0.05), and reduced liver tissue ROS content (p<0.05). [Conclusion] The results show that phycocyanin can improve the antioxidant capacity of mice, reduce oxidative damage to the body caused by irradiation, and provide a better protective effect on irradiation injury of mice.
WOS关键词	Nuclear Science & Technology
WOS研究方向	Nuclear Science & Technology ; 核科学与技术
语种	中文
CSCD记录号	CSCD:6154653
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24304]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.烟台大学药学院; 2.中国科学院烟台海岸带研究所; 3.兰州大学核科学与技术学院
推荐引用方式 GB/T 7714	刘琪,李文军,陆丽娜,等. 藻蓝蛋白对辐射致小鼠氧化损伤的保护作用[J]. 核技术,2018,41(1):10302-.
APA	刘琪.,李文军.,陆丽娜.,谢园园.,王明超.,...&杜振宁.(2018).藻蓝蛋白对辐射致小鼠氧化损伤的保护作用.核技术,41(1),10302-.
MLA	刘琪,et al."藻蓝蛋白对辐射致小鼠氧化损伤的保护作用".核技术 41.1(2018):10302-.