Polystyrene Encapsulated SERS Tags as Promising Standard Tools: Simple and Universal in Synthesis; Highly Sensitive and Ultrastable for Bioimaging

doi:10.1021/acs.analchem.9b00038

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 山东省海岸带环境工程技术研究中心

	Polystyrene Encapsulated SERS Tags as Promising Standard Tools: Simple and Universal in Synthesis; Highly Sensitive and Ultrastable for Bioimaging
	Yu, Q ; Wang, YQ ; Mei, RC ; Yin, YC ; You, JM ; Chen, LX
刊名	ANALYTICAL CHEMISTRY
	2019-04-16
卷号	91 期号:8 页码:5270-5277
关键词	ENHANCED RAMAN-SCATTERING LABEL-FREE DETECTION PHOTOTHERMAL ABLATION SHELL NANOPARTICLES GOLD NANOPARTICLES NANOPROBES PLATFORMS NANORODS
ISSN号	0003-2700
DOI	10.1021/acs.analchem.9b00038
产权排序	[Yu, Qian ; You, Jinmao ; Chen, Lingxin] Qufu Normal Univ, Dept Chem & Chem Engn, Qufu 273165, Peoples R China ; [Yu, Qian ; Wang, Yunqing ; Mei, Rongchao ; Yin, Yingchao ; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China ; [Wang, Yunqing ; Yin, Yingchao] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China ; [Chen, Lingxin] Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China
文献子类	Article
英文摘要	Surface coating determined the sensitivity and stability of surface enhanced Raman scattering (SERS) tags in bioanalysis. The reported various coatings suffered from the drawbacks of a lack of rigidity, stability, or synthesis versatility. Herein, we demonstrated robust polystyrene (PS) coated SERS tags that could be prepared by an easy and universal approach. Taking advantages of biocompatible, transparent, compact properties of PS shell, the coated tags showed satisfactory sensitivity, biocompatibility, and superior structural stability in cell and in vivo imaging applications. More importantly, the PS coating strategy allowed for the encapsulation of SERS tags encoded with not only thiolated but also nonthiolated Raman reporters without loss of sensitivity, as exemplified in the synthesis of 9 different resonant dye-encoded tags. Moreover, the coating of SERS tags with various kinds of substrates was achieved via the same standard protocol. Comparing with widespread silica coated tags, the PS coated ones were more stable in harsh conditions and had an easily expanded ultrasensitive (resonant) tags library with much lower cost (no need of expensive sulfhydryl/isothiocyano reporters with limited types), illustrating great promise as standard analytical tools of commercialized value for bioanalysis, medical diagnostics, and environmental science studies.
WOS关键词	ENHANCED RAMAN-SCATTERING ; LABEL-FREE DETECTION ; PHOTOTHERMAL ABLATION ; SHELL NANOPARTICLES ; GOLD NANOPARTICLES ; NANOPROBES ; PLATFORMS ; NANORODS
WOS研究方向	Chemistry, Analytical
语种	英语
WOS记录号	WOS:000465189600047
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81573393, 21575159] ; Youth Innovation Promotion Association CAS [2017256] ; Instrument Developing Project of the Chinese Academy of Sciences [YZ201662]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24956]
专题	烟台海岸带研究所_山东省海岸带环境工程技术研究中心烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; 2.Qufu Normal Univ, Dept Chem & Chem Engn, Qufu 273165, Peoples R China; 3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China 4.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Sch Pharm,Minist Educ, Yantai 264005, Peoples R China;
推荐引用方式 GB/T 7714	Yu, Q,Wang, YQ,Mei, RC,et al. Polystyrene Encapsulated SERS Tags as Promising Standard Tools: Simple and Universal in Synthesis; Highly Sensitive and Ultrastable for Bioimaging[J]. ANALYTICAL CHEMISTRY,2019,91(8):5270-5277.
APA	Yu, Q,Wang, YQ,Mei, RC,Yin, YC,You, JM,&Chen, LX.(2019).Polystyrene Encapsulated SERS Tags as Promising Standard Tools: Simple and Universal in Synthesis; Highly Sensitive and Ultrastable for Bioimaging.ANALYTICAL CHEMISTRY,91(8),5270-5277.
MLA	Yu, Q,et al."Polystyrene Encapsulated SERS Tags as Promising Standard Tools: Simple and Universal in Synthesis; Highly Sensitive and Ultrastable for Bioimaging".ANALYTICAL CHEMISTRY 91.8(2019):5270-5277.