The impact of ocean acidification and cadmium on the immune responses of Pacific oyster, Crassostrea gigas

doi:10.1016/j.fsi.2018.07.055

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	The impact of ocean acidification and cadmium on the immune responses of Pacific oyster, Crassostrea gigas
	Cao, Ruiwen ; Liu, Yongliang ; Wang, Qing ; Zhang, Qianqian ; Yang, Dinglong ; Liu, Hui ; Qu, Yi ; Zhao, Jianmin
刊名	FISH & SHELLFISH IMMUNOLOGY
	2018-10
卷号	81 页码:456-462
关键词	Ocean acidification Cadmium Crassostrea gigas Immune response
ISSN号	1050-4648
DOI	10.1016/j.fsi.2018.07.055
产权排序	[Cao, Ruiwen ; Liu, Yongliang ; Wang, Qing ; Zhang, Qianqian ; Yang, Dinglong ; Liu, Hui ; Qu, Yi ; Zhao, Jianmin] Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264117, Shandong, Peoples R China ; [Cao, Ruiwen ; Wang, Qing ; Zhang, Qianqian ; Yang, Dinglong ; Liu, Hui ; Qu, Yi] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai 264003, Shandong, Peoples R China ; [Cao, Ruiwen ; Qu, Yi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
文献子类	Article
英文摘要	Seawater acidification (OA) and cadmium (Cd) has the potential to lead to immunosuppression effect on marine bivalves. However, the interaction between these two environmental stressors on immune system of marine bivalves has received limited attention. In order to evaluate the defense responses of oysters under the combined exposure to OA and cadmium, the oysters Crassostrea gigas were exposed to 10 mu g/L Cd at three pH levels (8.1, 7.8 and 7.6) for 31 days. Results showed that OA exposure alone led to increased DNA damage, apoptosis rate and ROS production of hemocytes. However, inhibited phagocytosis rate, combined with increased DNA damage, apoptosis rate and ROS production of hemocytes were observed in oysters under exposure to Cd exposure alone or combined with OA. Significant interactive effects between OA and Cd were observed on ROS production and DNA damage of hemocytes. In addition, there is generally significant increase in the mRNA expression of genes related to immune-related TLR pathway and two immune factors (TNF and integrin beta-1B) in Cd-exposed oysters at pH 7.6. The results revealed that even though the mRNA expression of genes related to immune responses (TLR pathway and immune factors) was stimulated to counteract the immunosuppression caused by acidified seawater and Cd, depressed hemocyte function perhaps sensitized oysters to potential pathogen infection.
WOS关键词	SOLUBLE ADENYLYL-CYCLASE ; SIGNALING PATHWAYS ; PHYSIOLOGICAL-RESPONSES ; MARINE-ENVIRONMENT ; TOXICITY ; STRESS ; APOPTOSIS ; SEAWATER ; WATER ; PH
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种	英语
WOS记录号	WOS:000443665900054
资助机构	Chinese Academy of Sciences [XDA11020305, KZZDEW-14, YJKYYQ20170071] ; National Natural Science Foundation of China [31172388] ; Science and Technology Service Network Initiative (STS) Project [KFJ-STS-ZDTP-023] ; Youth Innovation Promotion Association, CAS [2016196]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24537]
专题	中国科学院牟平海岸带环境综合试验站烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室烟台海岸带研究所_近岸生态与环境实验室海岸带生物资源高效利用研究与发展中心
作者单位	1.Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264117, Shandong, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai 264003, Shandong, Peoples R China;
推荐引用方式 GB/T 7714	Cao, Ruiwen,Liu, Yongliang,Wang, Qing,et al. The impact of ocean acidification and cadmium on the immune responses of Pacific oyster, Crassostrea gigas[J]. FISH & SHELLFISH IMMUNOLOGY,2018,81:456-462.
APA	Cao, Ruiwen.,Liu, Yongliang.,Wang, Qing.,Zhang, Qianqian.,Yang, Dinglong.,...&Zhao, Jianmin.(2018).The impact of ocean acidification and cadmium on the immune responses of Pacific oyster, Crassostrea gigas.FISH & SHELLFISH IMMUNOLOGY,81,456-462.
MLA	Cao, Ruiwen,et al."The impact of ocean acidification and cadmium on the immune responses of Pacific oyster, Crassostrea gigas".FISH & SHELLFISH IMMUNOLOGY 81(2018):456-462.