Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor

doi:10.1021/acs.jmedchem.1c00433

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor
	Wang, Yue 2,3; Chen, Lingxin 1,2
刊名	JOURNAL OF MEDICINAL CHEMISTRY
	2021-03-25
卷号	64 期号:6 页码:2967-2970
ISSN号	0022-2623
DOI	10.1021/acs.jmedchem.1c00433
通讯作者	Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	Both nitroreductase and the folate receptor are highly expressed in hypoxic tumors. The folate receptor is a potential target for tumors, and nitroreductase can selectively turn on the fluorescence of probes by reducing the nitro group to an amino group. Karan et al. (Karana, S., Cho, M., Lee, H., Lee, H., Park, H., Sundararajan, M., Sessler, J., and Hong, K. Near-infrared fluorescent probe activated by nitroreductase for in vitro and in vivo hypoxic tumor detection. J. Med. Chem. 2021) developed a near-infrared fluorescent probe for hypoxia tumor imaging analysis in vitro and in vivo using folate as the targeting site. This promising strategy may promote advances in precision diagnosis and treatment models of malignant tumors. This Viewpoint looks ahead to new possibilities rendered by their studies.
资助项目	National Natural Science Foundation of China[21976209] ; Taishan Scholar Project Special Funding[Ts20190962]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000635440600007
资助机构	National Natural Science Foundation of China ; Taishan Scholar Project Special Funding
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/27235]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者	Chen, Lingxin
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yue,Chen, Lingxin. Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor[J]. JOURNAL OF MEDICINAL CHEMISTRY,2021,64(6):2967-2970.
APA	Wang, Yue,&Chen, Lingxin.(2021).Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor.JOURNAL OF MEDICINAL CHEMISTRY,64(6),2967-2970.
MLA	Wang, Yue,et al."Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor".JOURNAL OF MEDICINAL CHEMISTRY 64.6(2021):2967-2970.