Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9

doi:10.3390/molecules24244596

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	Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9
	Liu, YJ ; Zhang, JL ; Li, C ; Mu, XG ; Liu, XL ; Wang, L ; Zhao, YC ; Zhang, P ; Li, XD ; Zhang, XX
刊名	MOLECULES
	2019-12
卷号	24 期号:24 页码:4596
关键词	Aspergillus sydowii seawater-derived fungus secondary metabolites antimicrobial activity
DOI	10.3390/molecules24244596
产权排序	[Liu, Yu-Jing ; Zhang, Jian-Long ; Li, Chen ; Mu, Xue-Gen ; Liu, Xiao-Li ; Wang, Lei ; Zhao, Yan-Cui ; Li, Xiao-Dong ; Zhang, Xing-Xiao] Ludong Univ, Key Lab Marine Biotechnol Univ Shandong, Sch Life Sci, Yantai 264025, Peoples R China ; [Li, Xiao-Dong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China ; [Zhang, Jian-Long] Shandong Prov Key Lab Qual Safty Monitoring & Ris, Jinan 250022, Peoples R China ; [Zhang, Peng] Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China
文献子类	Article
英文摘要	Marine-derived fungi are considered to be valuable producers of bioactive secondary metabolites used as lead compounds with medicinal importance. In this study, chemical investigation of the seawater-derived fungus Aspergillus sydowii SW9 led to the isolation and identification of one new quinazolinone alkaloid, 2-(4-hydroxybenzyl)-4-(3-acetyl)quinazolin-one (1), one new aromatic bisabolene-type sesquiterpenoid, (2) and one new chorismic acid analogue (3), as well as two known alkaloids (compounds 4 and 5). Their structures were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of 2 and 3 were assigned by the analysis of ECD spectra aided by quantum chemical computations. Compounds 1, 2, and 4 exhibited selective inhibitory activities against the human pathogenic bacteria Escherichia coli, Staphylococcus aureus, S. epidermidis, and Streptococcus pneumoniae, with MIC values ranging from 2.0 to 16 mu g/mL.
WOS关键词	XANTHONE DERIVATIVES ; ENDOPHYTIC FUNGUS ; SYDONIC ACID ; ANALOGS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
语种	英语
WOS记录号	WOS:000507299600174
资助机构	National Key Research and Development Program of China [2016YFD0501010] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31700043, 41506190, 81600672] ; Key Research and Development Program of Shandong Province [2019GSF107091] ; Major Agricultural Applied Technological Innovation Projects of Shandong Province ; Key Research and Development Plan of Yantai [2018XSCC045] ; Innovation Team Project for Modern Agricultural Industrious Technology System of Shandong Province [SDAIT-11-10]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24797]
专题	烟台海岸带研究所_中科院烟台海岸带研究所知识产出
作者单位	1.Shandong Prov Key Lab Qual Safty Monitoring & Ris, Jinan 250022, Peoples R China; 2.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China 3.Ludong Univ, Key Lab Marine Biotechnol Univ Shandong, Sch Life Sci, Yantai 264025, Peoples R China; 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China;
推荐引用方式 GB/T 7714	Liu, YJ,Zhang, JL,Li, C,et al. Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9[J]. MOLECULES,2019,24(24):4596.
APA	Liu, YJ.,Zhang, JL.,Li, C.,Mu, XG.,Liu, XL.,...&Zhang, XX.(2019).Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9.MOLECULES,24(24),4596.
MLA	Liu, YJ,et al."Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9".MOLECULES 24.24(2019):4596.