Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges

doi:10.1177/0883911520981705

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院烟台海岸带研究所知识产出

	Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges
	Wang, Tong 4; Yang, Lintong 4; Wang, Guangfei 4; Han, Lei 4; Chen, Kaili 4; Liu, Ping 4; Xu, Shumin 4; Li, Dongsheng 3; Xie, Zeping 5; Mo, Xiumei 3
刊名	JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
	2021
卷号	36 期号:1 页码:44-58
关键词	tilapia skin collagen collagen sponge biocompatibility wound healing hemostatic properties
ISSN号	0883-9115
DOI	10.1177/0883911520981705
通讯作者	Zhang, Shumin(shumin_zhang@outlook.com) ; Gao, Yonglin(gylbill@163.com)
英文摘要	Dialyzed tilapia skin collagen sponge (DTSCS) and self-assembled tilapia skin collagen sponge (STSCS) were prepared by freeze-drying. The raw components used in the fabrication of DTSCS and STSCS were separated and purified from tilapia fish skin. It is anticipated that these collagen sponges could be developed into medical dressings for hemostasis and wound healing. The aim of the present research was to explore the possibility of DTSCS and STSCS as medical dressings and compare their differences by scanning electron microscopy (SEM), water absorption measurement, differential scanning calorimetry (DSC), measurement of porosity, cytotoxicity, hemolysis, in vivo biocompatibility, and evaluation of hemostatic performance and wound healing. The results indicate that DTSCS and STSCS are suitable materials for use in medical applications with a loose and porous structure, high water absorption, high porosity, and high thermal stability. The materials also displayed good biocompatibility, including excellent blood compatibility, a lack of cytotoxicity, with no apparent rejection following implantation. STSCS exhibited rapid hemostasis and promoted healing, with slightly greater efficacy than DTSCS. The hemostatic properties and promotion of healing in DTSCS was similar to that of commercial bovine collagen sponge. Therefore, DTSCS and STSCS both represented excellent potential candidate materials for use as hemostatic agents and wound dressings.
WOS研究方向	Biotechnology & Applied Microbiology ; Materials Science ; Polymer Science
语种	英语
WOS记录号	WOS:000605949700004
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/26155]
专题	烟台海岸带研究所_中科院烟台海岸带研究所知识产出中国科学院烟台海岸带研究所
通讯作者	Zhang, Shumin; Gao, Yonglin
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 2.Yantai Testing Ctr Food & Drug, Yantai, Peoples R China 3.Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai, Peoples R China 4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China 5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Wang, Tong,Yang, Lintong,Wang, Guangfei,et al. Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2021,36(1):44-58.
APA	Wang, Tong.,Yang, Lintong.,Wang, Guangfei.,Han, Lei.,Chen, Kaili.,...&Gao, Yonglin.(2021).Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges.JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,36(1),44-58.
MLA	Wang, Tong,et al."Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges".JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 36.1(2021):44-58.