Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction

doi:10.1039/c9cc00328b

CORC > 合肥物质科学研究院 > 中国科学院合肥物质科学研究院 > 中科院强磁场科学中心

	Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction
	Huang, Dong-Liang 1,3,5; Bai, Jing-Si 4; Wu, Meng 1; Wang, Xia 4; Riedl, Bernd 6; Pook, Elisabeth 2; Alt, Carsten 7,8; Erny, Marion 7; Li, Yi-Ming 4; Bierer, Donald 6
刊名	CHEMICAL COMMUNICATIONS
	2019-03-07
卷号	55 期号:19 页码:2821-2824
ISSN号	1359-7345
DOI	10.1039/c9cc00328b
通讯作者	Shi, Jing(shijing@ustc.edu.cn) ; Fang, Ge-Min(fanggm@ahu.edu.cn)
英文摘要	Previous studies have led to opposing hypotheses about the requirement of intermolecular disulfide exchange in the binding of the iron regulatory peptide hepcidin to its receptor ferroportin. To clarify this issue, we used the diaminodiacid approach to replace the disulfide bonds in hepcidin with non-reducible thioether bonds. Our results implied that disulfide exchange is not required for the interaction between hepcidin and ferroportin. This theory is further supported by our development of biologically active minihepcidins that do not show activity dependence on cysteine.
资助项目	National Key R&D Program of China[2017YFA0505400] ; NSFC[21572214] ; NSFC[21807001] ; NSFC[91753205]
WOS关键词	CHEMICAL-SYNTHESIS ; BINDING-SITE ; MINIHEPCIDINS ; ANALOGS ; MECHANISM ; PEPTIDES ; PROTEINS ; BRIDGES
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000460683700018
资助机构	National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; NSFC ; NSFC ; NSFC ; NSFC ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; NSFC ; NSFC ; NSFC ; NSFC
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/42375]
专题	合肥物质科学研究院_中科院强磁场科学中心
通讯作者	Shi, Jing; Fang, Ge-Min
作者单位	1.Anhui Univ, Inst Hlth Sci & Technol, Inst Phys Sci & Informat Technol, Sch Life Sci, Hefei 230601, Anhui, Peoples R China 2.Bayer AG, Lead Discovery Wuppertal, Wuppertal, Germany 3.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 4.Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Anhui, Peoples R China 5.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Peoples R China 6.Bayer AG, Dept Med Chem, Aprather Weg 18A, D-42096 Wuppertal, Germany 7.Bayer AG, Hematol Res, Wuppertal, Germany 8.Global Blood Therapeut, San Francisco, CA USA
推荐引用方式 GB/T 7714	Huang, Dong-Liang,Bai, Jing-Si,Wu, Meng,et al. Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction[J]. CHEMICAL COMMUNICATIONS,2019,55(19):2821-2824.
APA	Huang, Dong-Liang.,Bai, Jing-Si.,Wu, Meng.,Wang, Xia.,Riedl, Bernd.,...&Fang, Ge-Min.(2019).Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction.CHEMICAL COMMUNICATIONS,55(19),2821-2824.
MLA	Huang, Dong-Liang,et al."Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction".CHEMICAL COMMUNICATIONS 55.19(2019):2821-2824.