A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy | |
Sun, Xiao4; Zhang, Guilong4; Du, Ruohong1; Xu, Rui3; Zhu, Dongwang2; Qian, Junchao6; Bai, Guo2; Yang, Chi2; Zhang, Zhiyuan2; Zhang, Xin5 | |
刊名 | BIOMATERIALS |
2019-02-01 | |
卷号 | 194期号:无页码:151-160 |
关键词 | Microenvironment-responsive Degradable Combinatorial therapy Magnetic resonance imaging Nanotheranostics |
ISSN号 | 0142-9612 |
DOI | 10.1016/j.biomaterials.2018.12.004 |
英文摘要 | In this work, a tumor microenvironment (TME)-responsive biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging (MRI)-guided combinatorial cancer therapy was constructed. Fe3O4 nanoparticles decorated on the surface of MnSiO3 could effectively obstruct the pores of MnSiO3 and reduce the leakage of anticancer drugs under physiological conditions. The structure of the nanoplatform was broken under the weakly acidic and high-concentration glutathione conditions in the TME, resulting in the separation of the Fe3O4 nanoparticles from the nanoplatform and rapid drug release. In addition, the exfoliated Fe3O4 and released Mn2+ can help reduce the interference between their T-1 and T-2 contrast abilities, resulting in dual-mode MRI contrast enhancement. Furthermore, during the exfoliation process of the Fe3O4 nanocrystals, the catalytic activity of the Fe3O4 nanocrystals toward a Fenton-like reaction within cancer cells could be improved because of the increase in specific surface area, which led to the generation of highly toxic hydroxyl radicals and induced HeLa cell apoptosis. The nanoplatform also displayed excellent T-1-T-2 dual-mode MRI contrast enhancement and anticancer activity in vivo with reduced systemic toxicity. Thus, this multifunctional nanoplatform could be a potential nanotheranostic for dual-mode MRI-guided combinatorial cancer therapy. |
资助项目 | Youth Innovation Promotion Association of Chinese Academy of Sciences[2015385] ; Science and Technology Major Project of Anhui Province, China[17030701051] ; Natural Science Foundation of Anhui Province, China[1808085MB38] ; National Natural Science Foundation of China[21407151] ; National Natural Science Foundation of China[31870969] ; National Natural Science Foundation of China[81801039] ; Anhui Science and Technology Plan Project[1604a0802082] ; Anhui Science and Technology Plan Project[1401045013] ; Anhui Province Funds for Distinguished Young Scientists[1508085J08] ; Key Projects of the Outstanding Young Talents in Colleges and Universities[gxyqZD2016058] ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine[shkw2017] |
WOS关键词 | TUMOR ACCUMULATION ; CONTRAST AGENTS ; NANOPARTICLES ; NANOMATERIALS ; DELIVERY ; SIZE ; SUPERSTRUCTURES ; THERANOSTICS ; PENETRATION ; VIVO |
WOS研究方向 | Engineering ; Materials Science |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000457504900014 |
资助机构 | Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Science and Technology Major Project of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; Natural Science Foundation of Anhui Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Science and Technology Plan Project ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Anhui Province Funds for Distinguished Young Scientists ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Key Projects of the Outstanding Young Talents in Colleges and Universities ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine ; Gaofeng Clinical Medicine Grant Support from Shanghai Jiao Tong University School of Medicine |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/41895] |
专题 | 合肥物质科学研究院_技术生物与农业工程研究所 |
通讯作者 | Zou, Duohong; Wu, Zhengyan |
作者单位 | 1.Anhui Med Univ, Affiliated Hosp 1, Dept Stomatol, Hefei 230022, Anhui, Peoples R China 2.Shanghai Jiao Tong Univ, Natl Clin Res Ctr Stomatol, Peoples Hosp 9, Dept Oral Surg,Sch Med,Shanghai Key Lab Stomatol, Shanghai 200001, Peoples R China 3.Anhui Med Univ, Key Lab Oral Dis Res Anhui Prov, Stomatol Hosp & Coll, Dept Dent Implant Ctr, Hefei 230032, Anhui, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China 5.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Anhui, Peoples R China 6.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei Canc Hosp, Hefei 230031, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Xiao,Zhang, Guilong,Du, Ruohong,et al. A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy[J]. BIOMATERIALS,2019,194(无):151-160. |
APA | Sun, Xiao.,Zhang, Guilong.,Du, Ruohong.,Xu, Rui.,Zhu, Dongwang.,...&Wu, Zhengyan.(2019).A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy.BIOMATERIALS,194(无),151-160. |
MLA | Sun, Xiao,et al."A biodegradable MnSiO3@Fe3O4 nanoplatform for dual-mode magnetic resonance imaging guided combinatorial cancer therapy".BIOMATERIALS 194.无(2019):151-160. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论