Paramagnetic CuS hollow nanoflowers for T-2-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer | |
Zhang, Hao1,4,5; Chen, Yaodong3; Cai, Yunyu1,5; Liu, Jun1,5; Liu, Pengfei2; Li, Zizhuo3; An, Tingting3; Yang, Xiuhua3; Liang, Changhao1,4,5 | |
刊名 | BIOMATERIALS SCIENCE |
2019 | |
卷号 | 7期号:1页码:409-418 |
ISSN号 | 2047-4830 |
DOI | 10.1039/c8bm01412d |
英文摘要 | The development of nanoplatforms with integrated therapeutic and imaging functions is necessary for highly efficient cancer therapy. Herein, 3D CuS hollow nanoflowers (HNs) consisting of 2D nanoplates are successfully fabricated through the technique of laser ablation in liquids followed by ion-exchange reactions and applied for the first time as a theranostic nanoagent for magnetic resonance imaging (MRI), photothermal therapy (PTT), and chemotherapy simultaneously. Due to the sufficient and immediate contact between the exposed cupric centers of nanoplates and protons from water molecules, CuS HNs are demonstrated to be capable of being a T-1 positive contrast agent for efficient MRI of tumors on the T-2-weighted fluid-attenuated inversion recovery imaging (T-2-FLAIR) sequence. Besides, the hollow structure makes CuS HNs an efficient nanoplatform for drug loading with a laser-triggered drug release. Moreover, CuS HNs exhibit high photothermal conversion efficiency (30%) and good biocompatibility. The combination of PTT and chemotherapy with CuS HNs provides a significant synergistic therapeutic effect, resulting in a higher tumor inhibition ratio than PTT or chemotherapy alone. This study demonstrates a single-component multifunctional theranostic nanoagent for T-2-FLAIR MRI guided thermochemotherapy, which has great potential application in theranostics of cancer. |
资助项目 | National Basic Research Program of China[2014CB931704] ; National Natural Science Foundation of China (NSFC)[51571186] ; National Natural Science Foundation of China (NSFC)[11504375] ; National Natural Science Foundation of China (NSFC)[11674321] ; National Natural Science Foundation of China (NSFC)[11604320] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201627] |
WOS关键词 | PHOTOTHERMAL THERAPY ; DRUG-DELIVERY ; POLYDOPAMINE NANOPARTICLES ; CONVERSION EFFICIENCY ; SYNERGISTIC THERAPY ; CONTRAST AGENTS ; ABLATION ; NANOSPHERES ; NANOCRYSTALS ; PH |
WOS研究方向 | Materials Science |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000454085700028 |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/40824] |
专题 | 合肥物质科学研究院_中科院固体物理研究所 |
通讯作者 | Cai, Yunyu; Yang, Xiuhua; Liang, Changhao |
作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Anhui Key Lab Nanomat & Nanotechnol, Hefei 230031, Anhui, Peoples R China 2.Harbin Med Univ, Affiliated Hosp 1, Dept Magnet Resonance, Harbin 150001, Heilongjiang, Peoples R China 3.Harbin Med Univ, Affiliated Hosp 1, Dept Abdominal Ultrasound, Harbin 150001, Heilongjiang, Peoples R China 4.Univ Sci & Technol China, Dept Mat Sci & Engn, Hefei 230026, Peoples R China 5.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Hao,Chen, Yaodong,Cai, Yunyu,et al. Paramagnetic CuS hollow nanoflowers for T-2-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer[J]. BIOMATERIALS SCIENCE,2019,7(1):409-418. |
APA | Zhang, Hao.,Chen, Yaodong.,Cai, Yunyu.,Liu, Jun.,Liu, Pengfei.,...&Liang, Changhao.(2019).Paramagnetic CuS hollow nanoflowers for T-2-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer.BIOMATERIALS SCIENCE,7(1),409-418. |
MLA | Zhang, Hao,et al."Paramagnetic CuS hollow nanoflowers for T-2-FLAIR magnetic resonance imaging-guided thermochemotherapy of cancer".BIOMATERIALS SCIENCE 7.1(2019):409-418. |
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