Ecotoxicity Risk of Low-Dose Methylmercury Exposure to Caenorhabditis elegans: Multigenerational Toxicity and Population Discrepancy

doi:10.1021/acs.chemrestox.0c00518

	Ecotoxicity Risk of Low-Dose Methylmercury Exposure to Caenorhabditis elegans: Multigenerational Toxicity and Population Discrepancy
	Hu, Kunyu 3,4; Xu, Yun 4; Xu, Shengmin 1,5; Cheng, Lei 3,4; Zhou, Tong 4; Xie, Aidi 4; Xu, An 3,4; Wu, Lijun 1,3,4,5; Chen, Shaopeng 2,4
刊名	CHEMICAL RESEARCH IN TOXICOLOGY
	2021-04-19
卷号	34
ISSN号	0893-228X
DOI	10.1021/acs.chemrestox.0c00518
通讯作者	Wu, Lijun(ljw@ipp.ac.cn) ; Chen, Shaopeng(spchen035@ipp.ac.cn)
英文摘要	Methylmercury (MeHg) is a common organic form of mercury in water, which has been linked to several forms of biological toxicity. However, studies on the ecotoxicity risk of long-term exposure to low-dose MeHg are insufficient for the assessment of environmental safety. In the present study, the effects of MeHg on multiple generations (P0-F3) and population of Caenorhabditis elegans were investigated under long-term, low-dose exposure. We investigated the multigenerational toxicity of MeHg by analyzing reproductive and developmental indicators. According to our results, exposure to 100 nM MeHg had little effect on the parental generation (P0) but caused serious reproductive toxicity in the offspring (F1-F3), and the effect of MeHg was aggravated with each passing generation. The genes related to apoptosis and DNA damage were upregulated in the F3 generation. Pearson correlation analysis showed that the changes in these genes were closely related to the apoptosis of gonadal cells. Furthermore, chronic exposure to MeHg (from 100 to 1000 nM group) caused a sharp decline in population size and triggered the "bag of worms" phenotype. Genes related to vulvar development were downregulated in the F3 generation after treatment with 100 nM MeHg. These data suggest that long-term low-dose MeHg exposure adversely affected C. elegans and its offspring and triggered multigenerational toxicity and population discrepancy.
资助项目	Anhui Provincial Key RD Programmes[202004i07020016] ; Key Program of 13th five-year plan, CASHIPS[KP-2017-05] ; National Key Research and Development Project of China[2020YFC1808204]
WOS关键词	SILVER NANOPARTICLES ; REPRODUCTIVE TOXICITY ; BISPHENOL-A ; BIOACCUMULATION ; STRESS ; DAMAGE ; DEGENERATION ; ACTIVATION ; PATHWAYS ; PROMOTES
WOS研究方向	Pharmacology & Pharmacy ; Chemistry ; Toxicology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000642364000017
资助机构	Anhui Provincial Key RD Programmes ; Key Program of 13th five-year plan, CASHIPS ; National Key Research and Development Project of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/122131]
专题	中国科学院合肥物质科学研究院
通讯作者	Wu, Lijun; Chen, Shaopeng
作者单位	1.Anhui Univ, Inst Phys Sci, Hefei 230601, Peoples R China 2.Wannan Med Coll, Sch Publ Hlth, Wuhu 241002, Peoples R China 3.Univ Sci & Technol China, Sch Environm Sci & Optoelect Technol, Hefei 230026, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Key Lab Environm Toxicol & Pollut Control Technol, Hefei 230031, Peoples R China 5.Anhui Univ, Inst Informat Technol, Hefei 230601, Peoples R China
推荐引用方式 GB/T 7714	Hu, Kunyu,Xu, Yun,Xu, Shengmin,et al. Ecotoxicity Risk of Low-Dose Methylmercury Exposure to Caenorhabditis elegans: Multigenerational Toxicity and Population Discrepancy[J]. CHEMICAL RESEARCH IN TOXICOLOGY,2021,34.
APA	Hu, Kunyu.,Xu, Yun.,Xu, Shengmin.,Cheng, Lei.,Zhou, Tong.,...&Chen, Shaopeng.(2021).Ecotoxicity Risk of Low-Dose Methylmercury Exposure to Caenorhabditis elegans: Multigenerational Toxicity and Population Discrepancy.CHEMICAL RESEARCH IN TOXICOLOGY,34.
MLA	Hu, Kunyu,et al."Ecotoxicity Risk of Low-Dose Methylmercury Exposure to Caenorhabditis elegans: Multigenerational Toxicity and Population Discrepancy".CHEMICAL RESEARCH IN TOXICOLOGY 34(2021).