Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure

doi:10.1039/d1cc01767e

	Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure
	Sheng, Yaping 1; Cao, Bei 2,3; Ou, Mingxi 1; Wang, Yu 1; Yuan, Siming 1; Zhang, Na 4; Zou, Taotao 5; Liu, Yangzhong 1
刊名	CHEMICAL COMMUNICATIONS
	2021-04-28
ISSN号	1359-7345
DOI	10.1039/d1cc01767e
通讯作者	Zou, Taotao(zoutt3@mail.sysu.edu.cn) ; Liu, Yangzhong(liuyz@ustc.edu.cn)
英文摘要	NCp7 protein binds the duplex/quadruplex hybrid structure, which decreases the thermal stability of DNA and unfolds the G-quadruplex structure. Interestingly, the duplex in the stem-loop region is the more favorable binding site of NCp7. The NCp7 binding twists the top G-tetrad, weakens hydrogen bonding and causes K+ ejection, hence disrupting the G4 structure.
资助项目	National Key R&D Program of China[2017YFA0505400] ; National Science Foundation of China[21877103] ; Major Program of Development Foundation of Hefei Center for Physical Science and Technology[2018ZY FX004] ; Shenzhen Fundamental Research Fund[JCYJ20180 508163206306] ; Warshel Institute for Computational Biology from Shenzhen City and Longgang District, from Guangdong Science and Technology Department[2019Q N01C125] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515110508]
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000646724200001
资助机构	National Key R&D Program of China ; National Science Foundation of China ; Major Program of Development Foundation of Hefei Center for Physical Science and Technology ; Shenzhen Fundamental Research Fund ; Warshel Institute for Computational Biology from Shenzhen City and Longgang District, from Guangdong Science and Technology Department ; Guangdong Basic and Applied Basic Research Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121792]
专题	中国科学院合肥物质科学研究院
通讯作者	Zou, Taotao; Liu, Yangzhong
作者单位	1.Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Dept Chem,Dept Pharm, Hefei 230001, Anhui, Peoples R China 2.Chinese Univ Hong Kong, Warshel Inst Computat Biol, Shenzhen 518172, Peoples R China 3.Chinese Univ Hong Kong, Gen Educ Div, Shenzhen 518172, Peoples R China 4.Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Peoples R China 5.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China
推荐引用方式 GB/T 7714	Sheng, Yaping,Cao, Bei,Ou, Mingxi,et al. Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure[J]. CHEMICAL COMMUNICATIONS,2021.
APA	Sheng, Yaping.,Cao, Bei.,Ou, Mingxi.,Wang, Yu.,Yuan, Siming.,...&Liu, Yangzhong.(2021).Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure.CHEMICAL COMMUNICATIONS.
MLA	Sheng, Yaping,et al."Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure".CHEMICAL COMMUNICATIONS (2021).