BCL2L13: physiological and pathological meanings

doi:10.1007/s00018-020-03702-9

	BCL2L13: physiological and pathological meanings
	Meng, Fei 2,4,5; Sun, Naitong 3; Liu, Dongyan 2,4,5; Jia, Jia 2,4,5; Xiao, Jun 1; Dai, Haiming 2,4
刊名	CELLULAR AND MOLECULAR LIFE SCIENCES
	2021-03-01
卷号	78
关键词	BCL-rambo Autophagy Apoptosis Tumor Cerebrovascular accident Neurodegenerative disorders
ISSN号	1420-682X
DOI	10.1007/s00018-020-03702-9
通讯作者	Xiao, Jun(xiaojunpp@126.com) ; Dai, Haiming(daih@cmpt.ac.cn)
英文摘要	BCL2L13 is a BCL2-like protein. It has been discovered for two decades, now on the way to be a hotspot of research with its physiological and pathological meanings found in recent years. Start with the pro-apoptotic activity, there have been reported consecutively that BCL2L13 could also induce mitochondrial fragmentation, inhibit cell death and promote mitophagy. Similar to BNIP3, BCL2L13 cannot be indiscriminately categorized into pro- or anti-apoptotic proteins. It anchors in the mitochondrial outer membrane, and expresses in various cells and tissues. This article reviews for the first time that BCL2L13 functions in physiological processes, such as growth and development and energy metabolism, and its dysregulation participating in pathological processes, including cancer, bacterial infection, cardiovascular diseases and degenerative diseases, suggesting its important roles in these events.
资助项目	National Natural Science Foundation of China[31970701] ; National Natural Science Foundation of China[21772201] ; National Natural Science Foundation of China[82072807] ; Anhui Medical University ; Center of Medical Physics and Technology[LHJJ202006] ; Center of Medical Physics and Technology[LHJJ202007]
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	SPRINGER BASEL AG
WOS记录号	WOS:000642124100001
资助机构	National Natural Science Foundation of China ; Anhui Medical University ; Center of Medical Physics and Technology
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121717]
专题	中国科学院合肥物质科学研究院
通讯作者	Xiao, Jun; Dai, Haiming
作者单位	1.Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp USTC 1, Dept Urol, Hefei 230001, Peoples R China 2.Chinese Acad Sci, Hefei Canc Hosp, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China 3.Third Peoples Hosp Yancheng, Dept Hematol, Yancheng 224001, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China 5.Univ Sci & Technol China, Hefei 230026, Peoples R China
推荐引用方式 GB/T 7714	Meng, Fei,Sun, Naitong,Liu, Dongyan,et al. BCL2L13: physiological and pathological meanings[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2021,78.
APA	Meng, Fei,Sun, Naitong,Liu, Dongyan,Jia, Jia,Xiao, Jun,&Dai, Haiming.(2021).BCL2L13: physiological and pathological meanings.CELLULAR AND MOLECULAR LIFE SCIENCES,78.
MLA	Meng, Fei,et al."BCL2L13: physiological and pathological meanings".CELLULAR AND MOLECULAR LIFE SCIENCES 78(2021).