A large real-world cohort study of examined lymph node standards for adequate nodal staging in early non-small cell lung cancer

doi:10.21037/tlcr-20-1024

	A large real-world cohort study of examined lymph node standards for adequate nodal staging in early non-small cell lung cancer
	Zhu, Zhihua 1,2,3; Song, Zhengbo 4,5; Jiao, Wenjie 6; Mei, Weijian 1,2,3; Xu, Chunwei 7; Huang, Qinghua 8; An, Chaolun 9; Shi, Jianguang 10; Wang, Wenxian 4,5; Yu, Guiping 11
刊名	TRANSLATIONAL LUNG CANCER RESEARCH
	2021-02-01
卷号	10
关键词	Non-small cell lung cancer (NSCLC) examined lymph node (ELN) minimal number nodal staging cohort study
ISSN号	2218-6751
DOI	10.21037/tlcr-20-1024
通讯作者	Qian, Jun(qianjun_gz@126.com) ; Yao, Wang(yaow7@mail.sysu.edu.cn) ; Yang, Han(yanghan@sysucc.org.cn)
英文摘要	Background: The current National Comprehensive Cancer Network (NCCN) guidelines for non-small cell lung cancer (NSCLC) recommend that surgeons sample is not clear. We aimed to define a minimal number of examined lymph nodes for removal or sampling for optimized nodal staging recommendation, with a focus on T1-3N0M0 patients. Methods: A total of 55,101 consecutive patients were selected, including 52,099 patients with US Surveillance, Epidemiology, and End Results (SEER) data and 3,002 patients in a Chinese multicenter database from 11 thoracic referral centers, who underwent complete resection plus lymph node dissection or sampling for stage T1-3N0M0 NSCLC. Propensity score-matching analysis was performed with R software, and a cut-off value was calculated using X-tile software. Survival was evaluated using the Kaplan-Meier method and Cox proportional hazard models. Results: Five-year survival rates with respect to total examined lymph nodes numbers (examined lymph nodes <10 vs. examined lymph nodes >= 10) were 69% and 64% (group A), 66% and 63% (group B), 62% and 58% (group C), 81% and 75% (group D). There were significant differences between examined lymph nodes 10 and examined lymph nodes 10 in each group (P<0.001). Conclusions: A minimum of 10 examined lymph nodes would significantly improve T1-3N0M0 NSCLC prognosis and patients' survival rates if implemented as a minimum standard for lymphadenectomy. Therefore, we recommended a minimum of 10 examined lymph nodes for T1-3N0M0 patients.
资助项目	Medical Scientific Research Foundation of Guangdong Province[A2017356] ; Science and Technology Planning Project of Guangdong Province, China[2017A020219009]
WOS研究方向	Oncology ; Respiratory System
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000632493800016
资助机构	Medical Scientific Research Foundation of Guangdong Province ; Science and Technology Planning Project of Guangdong Province, China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121684]
专题	中国科学院合肥物质科学研究院
通讯作者	Qian, Jun; Yao, Wang; Yang, Han
作者单位	1.Sun Yat Sen Univ, Canc Ctr, 651 Dongfeng Rd East, Guangzhou 510060, Peoples R China 2.State Key Lab Oncol South China, 651 Dongfeng Rd East, Guangzhou 510060, Peoples R China 3.Collaborat Innovat Ctr Canc Med, 651 Dongfeng Rd East, Guangzhou 510060, Peoples R China 4.Univ Chinese Acad Sci, Canc Hosp, Hangzhou, Peoples R China 5.Zhejiang Canc Hosp, Hangzhou, Peoples R China 6.Qingdao Univ, Affiliated Hosp, Qingdao, Peoples R China 7.Fujian Canc Hosp, Fuzhou, Peoples R China 8.Guangxi Med Univ, Affiliated Tumor Hosp, Nanning, Peoples R China 9.Nantong Univ, Nantong Peoples Hosp 3, Nantong, Peoples R China 10.Zhejiang Univ, Ningbo Hosp 1, Ningbo, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Zhihua,Song, Zhengbo,Jiao, Wenjie,et al. A large real-world cohort study of examined lymph node standards for adequate nodal staging in early non-small cell lung cancer[J]. TRANSLATIONAL LUNG CANCER RESEARCH,2021,10.
APA	Zhu, Zhihua.,Song, Zhengbo.,Jiao, Wenjie.,Mei, Weijian.,Xu, Chunwei.,...&Yang, Han.(2021).A large real-world cohort study of examined lymph node standards for adequate nodal staging in early non-small cell lung cancer.TRANSLATIONAL LUNG CANCER RESEARCH,10.
MLA	Zhu, Zhihua,et al."A large real-world cohort study of examined lymph node standards for adequate nodal staging in early non-small cell lung cancer".TRANSLATIONAL LUNG CANCER RESEARCH 10(2021).