The association of CMTM6 expression with prognosis and PD-L1 expression in triple-negative breast cancer

doi:10.21037/atm-20-7616

	The association of CMTM6 expression with prognosis and PD-L1 expression in triple-negative breast cancer
	Tian, Yiping 3,4; Sun, Xiaohui 1; Cheng, Guoping 3,4; Ji, Enming 3,4; Yang, Shifeng 3,4; Feng, Jianguo 2,4; Zheng, Linfeng 3,4
刊名	ANNALS OF TRANSLATIONAL MEDICINE
	2021
卷号	9
关键词	CMTM6 PD-L1 triple-negative breast cancer (TNBC) immunohistochemistry (IHC) polymerase chain reaction (PCR) prognosis
ISSN号	2305-5839
DOI	10.21037/atm-20-7616
通讯作者	Zheng, Linfeng(zhenglf@zjcc.org.cn)
英文摘要	Background: Immune checkpoint inhibitors play a vital role in triple-negative breast cancer (TNBC) immunotherapy. A recent study showed that chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing 6 (CMTM6) has a crucial role in programmed death-ligand 1 (PD-L1) stability. The aim of this study was to investigate the relationship between CMTM6 and PD-L1 in TNBC and the association with clinical characteristics. Methods: A total of 143 patients, including 75 with human epidermal growth factor receptor 2 (HER2)-driven breast cancer and 68 with TNBC, were included in this study. In 83 paired primary breast cancers (PBCs) and metastatic breast cancers (MBC) comprising 45 HER2-driven breast cancers and 38 TNBC, CMTM6 and PD-L1 were detected based on immunohistochemistry (IHC) with FFPE tissues. Another 60 PBCs comprising 30 HER2-driven breast cancers and 30 TNBC in order to detect CMTM6 and PD-L1 mRNA expressions based on real-time polymerase chain reaction (RT-PCR) using frozen tissues. Furthermore, 153 patients comprising 30 TNBC and 123 HER2-driven breast cancer based on The Cancer Genome Atlas (TCGA) database were used to confirm the difference mRNA expression. Results: The expression of CMTM6 in patients with TNBC was significantly higher than in those with HER2-driven PBC (IHC, P=0.036, mRNA, P=0.036, TCGA dataset, P=0.039). CMTM6 was correlated with PD-L1 based on IHC in triple-negative MBC (P=0.004); the same result was found based on mRNA data in triple-negative PBC (P=0.021). Moreover, a high expression of CMTM6 in TNBC was associated with poor progression-free survival (PFS) (P=0.030, 95% CI: 1.08-4.57, HR=2.22). After multiple Cox regression analysis, CMTM6 in TNBC emerged as an independent risk factor for PFS (P=0.027, 95% CI: 1.11-5.20, HR=2.40). The expression of PD-L1 was negatively correlated with lymph node metastasis (P=0.026) and was not associated with PFS. Conclusions: The expression of CMTM6 was higher in TNBC than in HER2-driven breast cancer. In TNBC, CMTM6 was correlated with PD-L1 expression, and potentially could be used as an independent risk factor for predicting PFS.
资助项目	Medical Health Science and Technology Project of Zhejiang Provincial Health Commission[2018KY030] ; Natural Science Foundation of Zhejiang Province[LQ21H260001]
WOS研究方向	Oncology ; Research & Experimental Medicine
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000636046800009
资助机构	Medical Health Science and Technology Project of Zhejiang Provincial Health Commission ; Natural Science Foundation of Zhejiang Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121578]
专题	中国科学院合肥物质科学研究院
通讯作者	Zheng, Linfeng
作者单位	1.Zhejiang Chinese Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Dept Expt Res Ctr, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Dept Pathol, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Tian, Yiping,Sun, Xiaohui,Cheng, Guoping,et al. The association of CMTM6 expression with prognosis and PD-L1 expression in triple-negative breast cancer[J]. ANNALS OF TRANSLATIONAL MEDICINE,2021,9.
APA	Tian, Yiping.,Sun, Xiaohui.,Cheng, Guoping.,Ji, Enming.,Yang, Shifeng.,...&Zheng, Linfeng.(2021).The association of CMTM6 expression with prognosis and PD-L1 expression in triple-negative breast cancer.ANNALS OF TRANSLATIONAL MEDICINE,9.
MLA	Tian, Yiping,et al."The association of CMTM6 expression with prognosis and PD-L1 expression in triple-negative breast cancer".ANNALS OF TRANSLATIONAL MEDICINE 9(2021).