Decoding the Complex Free Radical Cascade by Using a DNA Framework-Based Artificial DNA Encoder

doi:10.1002/anie.202014088

	Decoding the Complex Free Radical Cascade by Using a DNA Framework-Based Artificial DNA Encoder
	Zhang, Lili 1; Wang, Linlin 1; Yuan, Xi 1; Zhong, Minjuan 1; Chen, Hong 1; Zhang, Dailiang 1; Han, Xiaoyan 1; Xie, Sitao 1; He, Lei 1; Li, Yazhou 1
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2021-04-01
关键词	DNA frameworks DNA nanotechnology free radical cascades molecular communication obesity
ISSN号	1433-7851
DOI	10.1002/anie.202014088
通讯作者	Liu, Yanlan(ylliu@hnu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn)
英文摘要	DNA-based molecular communications (DMC) are critical for regulating biological networks to maintain stable organismic functions. However, the complicated, time-consuming information transmission process involved in genome-coded DMC and the limited, vulnerable decoding activity generally lead to communication impairment or failure, in response to external stimuli. Herein, we present a conceptually innovative DMC strategy mediated by the DNA framework-based artificial DNA encoder. With the free-radical cascade as a proof-of-concept study, the artificial DNA encoder shows active sensing and real-time actuation, in situ and broad free radical-decoding efficacy, as well as robust resistance to environmental noise. It can also block undesirable short-to-medium-range communications between free radicals and inflammatory networks, leading to a synergistic anti-obesity effect. The artificial DNA encoder-based DMC may be generalized to other communication systems for a variety of applications.
资助项目	National Natural Science Foundation of China[NSFC21827811] ; National Natural Science Foundation of China[21877031] ; Science and Technology Innovation Program of Hunan Province[2018RS3043] ; Science and Technology Innovation Program of Hunan Province[2017XK2103] ; Key R&D Program of Hunan Province[2019SK2201] ; Young Thousand Talents Program
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000635646900001
资助机构	National Natural Science Foundation of China ; Science and Technology Innovation Program of Hunan Province ; Key R&D Program of Hunan Province ; Young Thousand Talents Program
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121156]
专题	中国科学院合肥物质科学研究院
通讯作者	Liu, Yanlan; Tan, Weihong
作者单位	1.Hunan Univ, Mol Sci & Biomed Lab MBL, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Aptamer Engn Ctr Hunan Prov, Changsha 410082, Hunan, Peoples R China 2.Chinese Acad Sci, Canc Hosp, Univ Chinese Acad Sci, Zhejiang Canc Hosp,Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China 3.Fdn Appl Mol Evolut, 13709 Progress Blvd, Alachua, FL 32615 USA
推荐引用方式 GB/T 7714	Zhang, Lili,Wang, Linlin,Yuan, Xi,et al. Decoding the Complex Free Radical Cascade by Using a DNA Framework-Based Artificial DNA Encoder[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021.
APA	Zhang, Lili.,Wang, Linlin.,Yuan, Xi.,Zhong, Minjuan.,Chen, Hong.,...&Tan, Weihong.(2021).Decoding the Complex Free Radical Cascade by Using a DNA Framework-Based Artificial DNA Encoder.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA	Zhang, Lili,et al."Decoding the Complex Free Radical Cascade by Using a DNA Framework-Based Artificial DNA Encoder".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021).