A Critical Role of Peptidylprolyl Isomerase A Pseudogene 22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma

doi:10.3389/fgene.2021.604461

	A Critical Role of Peptidylprolyl Isomerase A Pseudogene 22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma
	Gu, Yuwei 1; Wang, Chao 2; Chen, Shengsen 3,4; Tang, Jia 1; Guo, Xiaoxiao 1; Hu, Wei 5; Cui, An 1; Zhang, Dian 2; Yu, Kangkang 1; Chen, Mingquan 1,2
刊名	FRONTIERS IN GENETICS
	2021-03-15
卷号	12
关键词	hepatocellular carcinoma pseudogene PPIA chemokine macrophage
DOI	10.3389/fgene.2021.604461
通讯作者	Yu, Kangkang(ykk771395497@163.com) ; Chen, Mingquan(mingquanchen@fudan.edu.cn)
英文摘要	The burden of hepatocellular carcinoma (HCC) worldwide is increasing over time, while the underlying molecular mechanism of HCC development is still under exploration. Pseudogenes are classified as a special type of long non-coding RNAs (lncRNAs), and they played a vital role in regulating tumor-associated gene expression. Here, we report that a pseudogene peptidylprolyl isomerase A pseudogene 22 (PPIAP22) and its parental gene peptidylprolyl isomerase A (PPIA) were upregulated in HCC and were associated with the clinical outcomes of HCC. Further investigation revealed that PPIAP22 might upregulate the expression of PPIA through sponging microRNA (miR)-197-3p, behaving as competing endogenous RNA (ceRNA). PPIA could participate in the development of HCC by regulating mRNA metabolic process and tumor immunity based on the functional enrichment analysis. We also found a strong correlation between the expression levels of PPIA and the immune cell infiltration or the expression of chemokines, especially macrophage, C-C motif chemokine ligand 15 (CCL15), and C-X-C motif chemokine ligand 12 (CXCL12). Our findings demonstrate that the PPIAP22/miR-197-3p/PPIA axis plays a vital role in the progression of HCC by increasing the malignancy of tumor cells and regulating the immune cell infiltration, especially macrophage, through CCL15-CCR1 or CXCL12-CXCR4/CXCR7 pathways.
资助项目	National Natural Science Foundation of China[81773088]
WOS研究方向	Genetics & Heredity
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000634267700001
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121147]
专题	中国科学院合肥物质科学研究院
通讯作者	Yu, Kangkang; Chen, Mingquan
作者单位	1.Huashan Hosp, Dept Infect Dis, Shanghai, Peoples R China 2.Huashan Hosp, Emergency Dept, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Canc Hosp, Dept Endoscopy, Zhejiang Canc Hosp, Hangzhou, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 5.Fudan Univ, Shanghai Med Coll, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Gu, Yuwei,Wang, Chao,Chen, Shengsen,et al. A Critical Role of Peptidylprolyl Isomerase A Pseudogene 22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma[J]. FRONTIERS IN GENETICS,2021,12.
APA	Gu, Yuwei.,Wang, Chao.,Chen, Shengsen.,Tang, Jia.,Guo, Xiaoxiao.,...&Chen, Mingquan.(2021).A Critical Role of Peptidylprolyl Isomerase A Pseudogene 22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma.FRONTIERS IN GENETICS,12.
MLA	Gu, Yuwei,et al."A Critical Role of Peptidylprolyl Isomerase A Pseudogene 22/microRNA-197-3p/Peptidylprolyl Isomerase A Axis in Hepatocellular Carcinoma".FRONTIERS IN GENETICS 12(2021).