Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer

doi:10.21037/tcr-20-2744

	Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer
	Gong, Wangang 1,2; Chen, Yongyi 1,2; Zhang, Yingli 1,2
刊名	TRANSLATIONAL CANCER RESEARCH
	2021-02-01
卷号	10
关键词	Ovarian cancer (OC) SLC7A1 relapse-free survival
ISSN号	2218-676X
DOI	10.21037/tcr-20-2744
通讯作者	Zhang, Yingli(zhangyl@zjcc.org.cn)
英文摘要	Background: Members of the solute carrier (SLC)7 family are known to play important roles in tumorigenesis and development. However, the prognostic significance of the SLC7 family in ovarian cancer (OC) remains unknown. Methods: Expression patterns of SLC7 family members in OC were analyzed using gene expression profiling interactive analysis (GEPIA). The Kaplan-Meier plotter was applied to evaluate associations of the SLC7 gene family with prognosis of OC. SLC7A1 expression was additionally analyzed via immunohistochemical staining. chi(2), Kaplan-Meier and Cox regression analysis were used to evaluate the relationship between SLC7A1 expression and clinicopathological features, platinum resistance and prognosis in patients with high-grade serous ovarian cancer (HGSOC). Results: The GEPIA dataset revealed the abundant expression of SLC7A1, SLC7A4, and SLC7A7, and conversely, the low expression of SLC7A2 and SLC7A8 in OC relative to normal tissue samples. Kaplan-Meier survival analysis further indicated that high SLC7A1 and low SLC7A2 mRNA levels were significantly associated with overall survival (P<0.05). Positive SLC7A1 expression was detected in 65 (58.1%) HGSOC tissue samples, but not in all normal ovarian tissue samples (100%), indicating that the expression of SLC7A1 in HGSOC tissues was significantly higher than that in normal ovarian tissues (P<0.001). Additionally, expression of SLC7A1 was negatively associated with relapse-free survival (RFS; P<0.05). Conclusions: SLC7A1 is a potential prognostic biomarker of OC.
WOS关键词	SLC TRANSPORTERS ; EXPRESSION ; RESISTANCE
WOS研究方向	Oncology
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000624363300004
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/120909]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Yingli
作者单位	1.Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Gong, Wangang,Chen, Yongyi,Zhang, Yingli. Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer[J]. TRANSLATIONAL CANCER RESEARCH,2021,10.
APA	Gong, Wangang,Chen, Yongyi,&Zhang, Yingli.(2021).Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer.TRANSLATIONAL CANCER RESEARCH,10.
MLA	Gong, Wangang,et al."Prognostic and clinical significance of Solute Carrier Family 7 Member 1 in ovarian cancer".TRANSLATIONAL CANCER RESEARCH 10(2021).