Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study

doi:10.21037/gs-20-877

	Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study
	Xu, Dongni 1; Wang, Jiangling 2; Liu, Ting 1; Huang, Zhuoshan 3; Luo, Jianwei 1; Chen, Yuqing 1; Lu, Yanan 1
刊名	GLAND SURGERY
	2021-02-01
卷号	10
关键词	Resectable pancreatic cancer carbohydrate antigen 19-9 (CA19-9) abdominal and/or back pain primary tumor size lymph node metastasis prognosis pancreatitis
ISSN号	2227-684X
DOI	10.21037/gs-20-877
通讯作者	Chen, Yuqing(chenyq97@mail.sysu.edu.cn) ; Lu, Yanan(luynan@mail.sysu.edu.cn)
英文摘要	Background: Pancreatic ductal adenocarcinoma (PDAC) is one of malignant tumors with the worst prognosis. Surgery and adjuvant chemotherapy are the main treatments for resectable pancreatic cancer. For borderline resectable PDAC, neoadjuvant chemotherapy has been advised. For clearly resectable PDAC, neoadjuvant chemotherapy also might be considered for the patients with high-risk features, but with no precise quantitative criteria to define these features. So, this study aimed to re-evaluate the relationship between high-risk features and prognosis of clearly resectable pancreatic cancer, and to define the precise criteria for these high-risk features. Methods: Data from 211 patients with clearly resectable pancreatic cancer were reviewed to assess the relationship between overall survival (OS) after surgery and high-risk features, and cut-off values were determined for high-risk features that were associated with poor prognosis of clearly resectable pancreatic cancer. Results: Lymph node metastasis (LNM), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and primary tumor size >= 6 cm were significant variables related to OS. CA19-9 >= 1,000 U/mL was statistically related to prognosis, as was CA19-9 >= 500 U/mL without obstructive jaundice. There was no significant relationship between abdominal and/or back pain and OS, but patients with moderate or severe pain accompanied by tumor size >= 4 cm or 10 times higher CA19-9 levels had worse prognosis. Conclusions: For clearly resectable pancreatic cancer with R0 resection, the high-risk features were clarified. Abdominal and/or back pain may not be used as a prognostic indicator alone, though combined with CA19-9 or tumor size it may be more valuable for predicting prognosis.
资助项目	Guangdong Medical Science and Technology Research Fund[A2020240]
WOS关键词	ADJUVANT CHEMOTHERAPY ; GEMCITABINE ; SURVIVAL
WOS研究方向	Surgery
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000622479000026
资助机构	Guangdong Medical Science and Technology Research Fund
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/120902]
专题	中国科学院合肥物质科学研究院
通讯作者	Chen, Yuqing; Lu, Yanan
作者单位	1.Sun Yat Sen Univ, Dept Anesthesiol, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China 2.Chinese Acad Sci, Dept Anesthesiol, Canc Hosp, Hangzhou, Peoples R China 3.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Stomatol, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Xu, Dongni,Wang, Jiangling,Liu, Ting,et al. Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study[J]. GLAND SURGERY,2021,10.
APA	Xu, Dongni.,Wang, Jiangling.,Liu, Ting.,Huang, Zhuoshan.,Luo, Jianwei.,...&Lu, Yanan.(2021).Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study.GLAND SURGERY,10.
MLA	Xu, Dongni,et al."Quantitative definitions of pain, CA19-9, and tumor size as high-risk features of resectable pancreatic cancer: a single-center retrospective cohort study".GLAND SURGERY 10(2021).