Phospho-regulation and function of ULK1-ATG13 during the cell cycle

doi:10.1080/15548627.2021.1898750

	Phospho-regulation and function of ULK1-ATG13 during the cell cycle
	Li, Zhiyuan 2,3; Zhang, Xin 1,2
刊名	AUTOPHAGY
	2021-03-19
关键词	ULK1 ATG13 CDK1 autophagy mitosis
ISSN号	1554-8627
DOI	10.1080/15548627.2021.1898750
通讯作者	Zhang, Xin(xinzhang@hmfl.ac.cn)
英文摘要	Although it has been reported that some autophagy-related proteins could regulate the cell cycle, the function of ULK1-ATG13, the only protein kinase complex in macroautophagy/autophagy, remains unclear. We recently found that mitotic ULK1 and ATG13 are both substrates of the key cell cycle regulator CDK1-CCNB/cyclin B. CDK1-induced ULK1-ATG13 phosphorylation promotes mitotic autophagy and cell cycle progression. Moreover, ULK1 and ATG13 double-knockout significantly inhibits cell cycle progression and tumor cell proliferation in vitro and in vivo. These findings bridge the mutual regulation between autophagic and mitotic key kinases and provide a theoretical basis for autophagy- and cell division-related diseases based on combination therapy.
资助项目	National Key Research and Development Program of China[2016YFA0400900] ; CASHIPS Director's Fund[YZJJ2019QN17] ; Anhui Natural Science Foundation[1908085MC88] ; National Natural Science Foundation of China[31900508]
WOS研究方向	Cell Biology
语种	英语
出版者	TAYLOR & FRANCIS INC
WOS记录号	WOS:000629818200001
资助机构	National Key Research and Development Program of China ; CASHIPS Director's Fund ; Anhui Natural Science Foundation ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/120862]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Xin
作者单位	1.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, High Magnet Field Lab, Hefei, Peoples R China 3.Univ Dundee, Med Res Council, Prot Phosphorylat & Ubiquitylat Unit, Sch Life Sci, Dundee, Scotland
推荐引用方式 GB/T 7714	Li, Zhiyuan,Zhang, Xin. Phospho-regulation and function of ULK1-ATG13 during the cell cycle[J]. AUTOPHAGY,2021.
APA	Li, Zhiyuan,&Zhang, Xin.(2021).Phospho-regulation and function of ULK1-ATG13 during the cell cycle.AUTOPHAGY.
MLA	Li, Zhiyuan,et al."Phospho-regulation and function of ULK1-ATG13 during the cell cycle".AUTOPHAGY (2021).