Biodegradable Zn-3Cu and Zn-3Cu-0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications

doi:10.1016/j.jmst.2020.06.052

	Biodegradable Zn-3Cu and Zn-3Cu-0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications
	Lin, Jixing 2; Tong, Xian 1,2; Wang, Kun 2; Shi, Zimu 3; Li, Yuncang 4; Dargusch, Matthew 5; Wen, Cuie 4
刊名	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
	2021-03-30
卷号	68
关键词	Cytotoxicity Degradation behavior Mechanical properties Zn-Cu biodegradable metals
ISSN号	1005-0302
DOI	10.1016/j.jmst.2020.06.052
通讯作者	Lin, Jixing(linjixing@163.com) ; Tong, Xian(tx847595271@163.com) ; Wen, Cuie(cuie.wen@rmit.edu.au)
英文摘要	Zinc (Zn) and its alloys have been proposed as biodegradable implant materials due to their unique combination of biodegradability, biocompatibility, and biofunctionality. However, the insufficient mechanical properties of pure Zn greatly limit its clinical application. Here, we report on the microstructure, mechanical properties, friction and wear behavior, corrosion and degradation properties, hemocompatibility, and cytocompatibility of Zn-3Cu and Zn-3Cu-0.2Ti alloys under three different conditions of as-cast (AC), hot-rolling (HR), and hot-rolling plus cold-rolling (HR + CR). The HR + CR Zn-3Cu-0.2Ti exhibited the best set of comprehensive properties among all the alloy samples, with yield strength of 211.0 MPa, ultimate strength of 271.1 MPa, and elongation of 72.1 %. Immersion tests of the Zn-3Cu and Zn-3Cu-0.2Ti alloys in Hanks' solution for 3 months indicated that the AC samples showed the lowest degradation rate, followed by the HR samples, and then the HR + CR samples, while the HR + CR Zn-3Cu exhibited the highest degradation rate of 23.9 mu m/a. Friction and wear testing of the Zn-3Cu and Zn-3Cu-0.2Ti alloys in Hanks' solution indicated that the AC samples showed the highest wear resistance, followed by the HR samples, and then the HR + CR samples, while the AC Zn-3Cu-0.2Ti showed the highest wear resistance. The diluted extracts of HR + CR Zn-3Cu and Zn-3Cu-0.2Ti at a concentration of <= 25 % exhibited noncytotoxicity. Furthermore, both the HR + CR Zn-3Cu and Zn-3Cu-0.2Ti exhibited effective antibacterial properties against S. aureus. (C) 2021 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
资助项目	Research Funds of the Wenzhou Science and Technology Bureau[ZG2019022] ; Research Funds of the Wenzhou Science and Technology Bureau[2018ZG008] ; Australian Research Council (ARC)[DP170102557] ; Australian Research Council (ARC)[FT160100252] ; ARC Research Hub for Advanced Manufacturing of Medical Devices[IH150100024]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
语种	英语
出版者	JOURNAL MATER SCI TECHNOL
WOS记录号	WOS:000623854600010
资助机构	Research Funds of the Wenzhou Science and Technology Bureau ; Australian Research Council (ARC) ; ARC Research Hub for Advanced Manufacturing of Medical Devices
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/120835]
专题	中国科学院合肥物质科学研究院
通讯作者	Lin, Jixing; Tong, Xian; Wen, Cuie
作者单位	1.Xiangtan Univ, Sch Mat Sci & Engn, Xiangtan 411105, Peoples R China 2.Zhejiang Ind & Trade Vocat Coll, Dept Mat Engn, Wenzhou 325003, Peoples R China 3.Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Peoples R China 4.RMIT Univ, Sch Engn, Melbourne, Vic 3001, Australia 5.Univ Queensland, Ctr Adv Mat Proc & Mfg AMPAM, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	Lin, Jixing,Tong, Xian,Wang, Kun,et al. Biodegradable Zn-3Cu and Zn-3Cu-0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,68.
APA	Lin, Jixing.,Tong, Xian.,Wang, Kun.,Shi, Zimu.,Li, Yuncang.,...&Wen, Cuie.(2021).Biodegradable Zn-3Cu and Zn-3Cu-0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,68.
MLA	Lin, Jixing,et al."Biodegradable Zn-3Cu and Zn-3Cu-0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 68(2021).