Multi-scale simulation of early kidney branching morphogenesis

doi:10.1088/1478-3975/abd844

	Multi-scale simulation of early kidney branching morphogenesis
	Cai, Wenran 1; Wang, Yunqi 2,3; Zhang, Jicong 2,3; Zhang, Hong 4; Luo, Tianzhi 1
刊名	PHYSICAL BIOLOGY
	2021-03-01
卷号	18
关键词	branch morphogenesis kidney development repulsion random work dihedral angle
ISSN号	1478-3967
DOI	10.1088/1478-3975/abd844
通讯作者	Luo, Tianzhi(tzluo@ustc.edu.cn)
英文摘要	An important feature of the branch morphogenesis during kidney development is the termination of the tips on the outer surface of a kidney. This feature requires the avoidance of the intersection between the tips and existing ducts inside the kidney. Here, we started from a continuous model and implemented the coarse grained rules into a fast and discrete simulations. The ligand-receptor-based Turing mechanism suggests a repulsion that decreases exponentially with distance between interacting branches, preventing the intersection between neighboring branches. We considered this repulsive effect in numerical simulations and successfully reproduce the key features of the experimentally observed branch morphology for an E15.5 kidney. We examine the similarity of several geometrical parameters between the simulation results and experimental observations. The good agreement between the simulations and experiments suggests that the concentration decay caused by the absorption of glial cell line derived neurotrophic factor might be the key factor to affect the geometry in early kidney development.
资助项目	National Science Foundation of China[11572316] ; National Science Foundation of China[21777165] ; Fundamental Research Funds for the Central Universities[WK2480000006] ; Anhui Province Science and Technology Major Project[201903a07020019]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	IOP PUBLISHING LTD
WOS记录号	WOS:000621501100001
资助机构	National Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Anhui Province Science and Technology Major Project
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/120634]
专题	中国科学院合肥物质科学研究院
通讯作者	Luo, Tianzhi
作者单位	1.Univ Sci & Technol China, Dept Modern Mech, CAS Key Lab Mech Behav & Design Mat, Hefei, Peoples R China 2.Beihang Univ, Sch Biol Sci & Med Engn, Beijing, Peoples R China 3.Beihang Univ, Hefei Innovat Res Inst, Hefei, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Shushanhu Rd 350, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Cai, Wenran,Wang, Yunqi,Zhang, Jicong,et al. Multi-scale simulation of early kidney branching morphogenesis[J]. PHYSICAL BIOLOGY,2021,18.
APA	Cai, Wenran,Wang, Yunqi,Zhang, Jicong,Zhang, Hong,&Luo, Tianzhi.(2021).Multi-scale simulation of early kidney branching morphogenesis.PHYSICAL BIOLOGY,18.
MLA	Cai, Wenran,et al."Multi-scale simulation of early kidney branching morphogenesis".PHYSICAL BIOLOGY 18(2021).