Biodegradable Zn-3Mg-0.7Mg(2)Si composite fabricated by high-pressure solidification for bone implant applications

doi:10.1016/j.actbio.2020.12.059

	Biodegradable Zn-3Mg-0.7Mg(2)Si composite fabricated by high-pressure solidification for bone implant applications
	Tong, Xian 1,2,3; Cai, Wenhao 1; Lin, Jixing 2,3; Wang, Kun 3; Jin, Lufan 3; Shi, Zimu 4; Zhang, Dechuang 1; Lin, Jianguo 1; Li, Yuncang 5; Dargusch, Matthew 6
刊名	ACTA BIOMATERIALIA
	2021-03-15
卷号	123
关键词	Biodegradable metal Friction and wear High-pressure solidification In vitro biocompatibility Zn-based composite
ISSN号	1742-7061
DOI	10.1016/j.actbio.2020.12.059
通讯作者	Lin, Jixing(linjixing@163.com) ; Wang, Kun(wangkunccc@163.com) ; Wen, Cuie(cuie.wen@rmit.edu.au)
英文摘要	Zinc (Zn)-based alloys have been considered potential biodegradable materials for medical applications due to their good biodegradability and biocompatibility. However, the insufficient mechanical properties of pure Zn do not meet the requirements of biodegradable implants. In this study, we have developed a biodegradable Zn-3Mg-0.7Mg(2)Si composite fabricated by high-pressure solidification. Microstructural characterization revealed that the high-pressure solidified (HPS) composite exhibited uniformly distributed fine MgZn2 granules in an alpha-Zn matrix. Comprehensive tests indicated that the HPS composite exhibited exceptionally high compression properties including a compressive yield strength of 406.2 MPa, an ultimate compressive strength of 1181.2 MPa, and plastic deformation up to 60% strain without cracking or fracturing. Potentiodynamic polarization tests revealed that the HPS composite showed a corrosion potential of -0.930 V, a corrosion current density of 3.5 mu A/cm(2), and a corrosion rate of 46.2 mu m/y. Immersion tests revealed that the degradation rate of the HPS composite after immersion in Hanks' solution for 1 month and 3 months was 42.8 mu m/y and 37.8 mu m/y, respectively. Furthermore, an extract of the HPS composite exhibited good cytocompatibility compared with as-cast (AC) pure Zn and an AC composite at a concentration of <= 25%. These results suggest that the HPS Zn-3Mg-0.7Mg(2)Si composite can be anticipated as a promising biodegradable material for orthopedic applications. Statement of significance This work reports a biodegradable Zn-3Mg-0.7Mg(2)Si composite fabricated by high-pressure solidification. Our findings demonstrated that the high-pressure solidified (HPS) composite exhibited exceptionally high compression properties, including a compressive yield strength of 406.2 MPa, an ultimate compressive strength of 1181.2 MPa, and a plastic deformation up to 60% strain without cracking nor fracturing due to the formation of a uniformly distributed phase of fine MgZn2 particles in the alpha-Zn matrix. The extract of the HPS composite exhibited a better cytocompatibility compared to its as-cast counterpart and the as-cast pure Zn. This HPS Zn-based composite is anticipated to be a promising biodegradable orthopedic material due to its mechanical properties and acceptable cytotoxicity. (C) 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
资助项目	Wenzhou Science and Technology Bureau[ZG2020020] ; Wenzhou Science and Technology Bureau[ZG2019022] ; Australian Research Council (ARC)[DP170102557] ; Australian Research Council (ARC)[FT160100252] ; ARC Research Hub for Advanced Manufacturing of Medical Devices[IH150100024] ; National Natural Science Foundation of China[11872053] ; National Natural Science Foundation of China[51971190]
WOS研究方向	Engineering ; Materials Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000622098300010
资助机构	Wenzhou Science and Technology Bureau ; Australian Research Council (ARC) ; ARC Research Hub for Advanced Manufacturing of Medical Devices ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/120463]
专题	中国科学院合肥物质科学研究院
通讯作者	Lin, Jixing; Wang, Kun; Wen, Cuie
作者单位	1.Xiangtan Univ, Sch Mat Sci & Engn, Xiangtan 411105, Peoples R China 2.Wenzhou Med Univ, Sch & Hosp Stomatol, Wenzhou 325027, Peoples R China 3.Zhejiang Ind & Trade Vocat Coll, Dept Mat Engn, Wenzhou 325003, Peoples R China 4.Chinese Acad Sci, Inst Solid State Phys, Key Lab Mat Phys, Hefei 230031, Peoples R China 5.RMIT Univ, Sch Engn, Melbourne, Vic 3001, Australia 6.Univ Queensland, Ctr Adv Mat Proc & Mfg AMPAM, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	Tong, Xian,Cai, Wenhao,Lin, Jixing,et al. Biodegradable Zn-3Mg-0.7Mg(2)Si composite fabricated by high-pressure solidification for bone implant applications[J]. ACTA BIOMATERIALIA,2021,123.
APA	Tong, Xian.,Cai, Wenhao.,Lin, Jixing.,Wang, Kun.,Jin, Lufan.,...&Wen, Cuie.(2021).Biodegradable Zn-3Mg-0.7Mg(2)Si composite fabricated by high-pressure solidification for bone implant applications.ACTA BIOMATERIALIA,123.
MLA	Tong, Xian,et al."Biodegradable Zn-3Mg-0.7Mg(2)Si composite fabricated by high-pressure solidification for bone implant applications".ACTA BIOMATERIALIA 123(2021).