In Situ One-Pot Synthesis of Fe2O3@BSA Core-Shell Nanoparticles as Enhanced T-1-Weighted Magnetic Resonance Imagine Contrast Agents

doi:10.1021/acsami.0c13825

	In Situ One-Pot Synthesis of Fe2O3@BSA Core-Shell Nanoparticles as Enhanced T-1-Weighted Magnetic Resonance Imagine Contrast Agents
	Xu, Shuai 2,3; Wang, Jiarong 2; Wei, Yuan 4; Zhao, Hongxin 2; Tao, Tongxiang 2,3; Wang, Hui 2; Wang, Zhen 2,3; Du, Juan 4; Wang, Hongzhi 1; Qian, Junchao 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2020-12-23
卷号	12
关键词	BSA nanocage ultra-small iron oxide nanoparticles T-1 contrast agent magnetic resonance angiography biocompatibility renal clearance
ISSN号	1944-8244
DOI	10.1021/acsami.0c13825
通讯作者	Qian, Junchao(qianjunchao@hmfl.ac.cn) ; Ma, Kun(makun@hmfl.ac.cn) ; Wang, Junfeng(junfeng@hmfl.ac.cn)
英文摘要	Ultra-small-sized iron oxide nanoparticles with good biocompatibility are regarded as promising alternatives for the gadolinium-based contrast agents, which are widely used as a positive contrast agent in magnetic resonance imaging (MRI). However, the current preparation of the iron oxide magnetic nanoparticles with small sizes usually involves organic solvents, increasing the complexity of hydrophilic ligand replacement and reducing the synthesis efficiency. It remains a great challenge to explore new iron oxide nanoparticles with good biocompatibility and a high T-1 contrast effect. Here, we reported a cage-like protein architecture self-assembled by approximately 6-7 BSA (bovine serum albumin) subunits. The BSA nanocage was then used as a biotemplate to synthesize uniformed and monodispersed Fe2O3@BSA nanoparticles with ultra-small sizes (similar to 3.5 nm). The Fe2O3@BSA nanoparticle showed a high r(1) value of 6.8 mM(-1)s(-1) and a low r(2)/r(1) ratio of 10.6 at a 3 T magnetic field. Compared to Gd-DTPA, the brighter signal and prolonged angiographic effect of Fe2O3@BSA nanoparticles could greatly benefit steady-state and high-resolution imaging. The further in vivo and in vitro assessments of stability, toxicity, and renal clearance indicated a substantial potential as a T-1 contrast agent in preclinical MRI.
资助项目	National Natural Science Foundation of China[3190110313] ; National Natural Science Foundation of China[U1632274] ; National Natural Science Foundation of China[8197102295] ; National Natural Science Foundation of China[U1732157] ; Ministry of Science and Technology of China[2016YFA0400901] ; High Magnetic Field Laboratory of Anhui Province
WOS关键词	IRON-OXIDE NANOPARTICLES ; INORGANIC NANOPARTICLES ; LIGAND-EXCHANGE ; FERRITIN ; PROTEIN ; FE3O4 ; IONS ; MRI ; NANOSTRUCTURES ; NANOCRYSTALS
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000603397200004
资助机构	National Natural Science Foundation of China ; Ministry of Science and Technology of China ; High Magnetic Field Laboratory of Anhui Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/120014]
专题	中国科学院合肥物质科学研究院
通讯作者	Qian, Junchao; Ma, Kun; Wang, Junfeng
作者单位	1.Chinese Acad Sci, Hefei Canc Hosp, Anhui Prov Key Lab Med Phys & Technol, Inst Hlth & Med Technol,Hefei Inst Phys Sci, Hefei 230031, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, CAS Key Lab High Magnet Field & Ion Beam Phys Bio, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Hefei 230036, Peoples R China 4.Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Peoples R China 5.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Xu, Shuai,Wang, Jiarong,Wei, Yuan,et al. In Situ One-Pot Synthesis of Fe2O3@BSA Core-Shell Nanoparticles as Enhanced T-1-Weighted Magnetic Resonance Imagine Contrast Agents[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12.
APA	Xu, Shuai.,Wang, Jiarong.,Wei, Yuan.,Zhao, Hongxin.,Tao, Tongxiang.,...&Wang, Junfeng.(2020).In Situ One-Pot Synthesis of Fe2O3@BSA Core-Shell Nanoparticles as Enhanced T-1-Weighted Magnetic Resonance Imagine Contrast Agents.ACS APPLIED MATERIALS & INTERFACES,12.
MLA	Xu, Shuai,et al."In Situ One-Pot Synthesis of Fe2O3@BSA Core-Shell Nanoparticles as Enhanced T-1-Weighted Magnetic Resonance Imagine Contrast Agents".ACS APPLIED MATERIALS & INTERFACES 12(2020).