Lipid-oligonucleotide conjugates for bioapplications

doi:10.1093/nsr/nwaa161

	Lipid-oligonucleotide conjugates for bioapplications
	Li, Xiaowei 2,3,4; Feng, Kejun 1,2,3,4; Li, Long 2,3,4; Yang, Lu 2,3,4; Pan, Xiaoshu 2,3,4; Yazd, Hoda Safari 2,3,4; Cui, Cheng 2,3,4,5,6,7,8; Li, Juan 7,8; Moroz, Leonid 2,3,4; Sun, Yujia 2,3,4,7,8
刊名	NATIONAL SCIENCE REVIEW
	2020-12-01
卷号	7
关键词	lipid-oligonucleotide DNA nanostructure biosensor biomedicine bio analysis nanoreactor
ISSN号	2095-5138
DOI	10.1093/nsr/nwaa161
通讯作者	Tan, Weihong(tan@hnu.edu.cn)
英文摘要	Lipid-oligonucleotide conjugates (LONs) are powerful molecular-engineering materials for various applications ranging from biosensors to biomedicine. Their unique amphiphilic structures enable the self-assembly and the conveyance of information with high fidelity. In particular, LONs present remarkable potential in measuring cellular mechanical forces and monitoring cell behaviors. LONs are also essential sensing tools for intracellular imaging and have been employed in developing cell-surface-anchored DNA nanostructures for biomimetic-engineering studies. When incorporating therapeutic oligonucleotides or small-molecule drugs, LONs hold promise for targeted therapy. Moreover, LONs mediate the controllable assembly and fusion of vesicles based on DNA-strand displacements, contributing to nanoreactor construction and macromolecule delivery. In this review, we will summarize the general synthesis strategies of LONs, provide some characterization analysis and emphasize recent advances in bioanalytical and biomedical applications. We will also consider the relevant challenges and suggest future directions for building better functional LONs in nanotechnology and materials-science applications.
资助项目	National Natural Science Foundation of China[21827811] ; Science and Technology Project of Hunan Province[2017XK2103] ; Hunan Provincial Key Area RD Program[2019SK2201]
WOS关键词	SOLID-PHASE SYNTHESIS ; SPHERICAL NUCLEIC-ACIDS ; DNA MICELLE FLARES ; IN-VIVO DELIVERY ; MOLECULAR RECOGNITION ; APTAMER-MICELLE ; VESICLE FUSION ; GENE DELIVERY ; CO-DELIVERY ; LIVE CELLS
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000606157200025
资助机构	National Natural Science Foundation of China ; Science and Technology Project of Hunan Province ; Hunan Provincial Key Area RD Program
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/119695]
专题	中国科学院合肥物质科学研究院
通讯作者	Tan, Weihong
作者单位	1.Huizhou Univ, Sch Chem & Mat Engn, Huizhou 516007, Peoples R China 2.Univ Florida, Ctr Res Bio Nano Interface, Dept Chem, Hlth Canc Ctr, Gainesville, FL 32611 USA 3.Univ Florida, Dept Physiol & Funct Genom, Hlth Canc Ctr, UF Genet Inst, Gainesville, FL 32611 USA 4.Univ Florida, McKnight Brain Inst, Hlth Canc Ctr, Gainesville, FL 32611 USA 5.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou 310022, Peoples R China 6.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Peoples R China 7.Hunan Univ, Mol Sci & Biomed Lab MBL, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Coll Biol, Changsha 410082, Hunan, Peoples R China 8.Hunan Univ, Aptamer Engn Ctr Hunan Prov, Changsha 410082, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiaowei,Feng, Kejun,Li, Long,et al. Lipid-oligonucleotide conjugates for bioapplications[J]. NATIONAL SCIENCE REVIEW,2020,7.
APA	Li, Xiaowei.,Feng, Kejun.,Li, Long.,Yang, Lu.,Pan, Xiaoshu.,...&Tan, Weihong.(2020).Lipid-oligonucleotide conjugates for bioapplications.NATIONAL SCIENCE REVIEW,7.
MLA	Li, Xiaowei,et al."Lipid-oligonucleotide conjugates for bioapplications".NATIONAL SCIENCE REVIEW 7(2020).